Burmao?lu S.Çelik H.Göiksu S.Maraş A.Altundaş R.Seçen H.20.04.20192019-04-2020.04.20192019-04-2020090039-7911https://dx.doi.org/10.1080/00397910802542036https://hdl.handle.net/20.500.12403/979The first total synthesis of (4E,6E)-1,7-bis(3,4-dihydroxyphenyl)-hepta-4, 6-dien-3-one and an alternative synthesis of (4E,6E)-1,7-bis(4-hydroxyphenyl)- hepta-4,6-dien-3-one, two natural diarylheptanoids, mainly based on Claisen-Schmidt condensation were described. The crucial steps of the syntheses were the condensation of OH-protected 4-aryl-2-butanones with OH-protected 3-aryl-acrylaldehydes by the in situ enamination and then deprotection of OH groups to give the corresponding natural diarylheptanoids. Copyright © Taylor & Francis Group, LLC.eninfo:eu-repo/semantics/closedAccess1,7-Bis(3,4-dihydroxyphenyl)-hepta-4,6-dien-3-one1,7-bis(4-hydroxyphenyl)- hepta-46-dien-3-oneClaisen-Schmidt condensationdiarylheptanoidin situ enaminationsynthesis1,7 bis(3,4 dihydroxyphenyl) hepta 4,6 dien 3 one1,7 bis(4 hydroxyphenyl) hepta 4,6 dien 3 onealnustonenatural productunclassified drugaminationarticleClaisen condensationdeprotection reactiondrug structuredrug synthesisproton nuclear magnetic resonance1,7-Bis(3,4-dihydroxyphenyl)-hepta-4,6-dien-3-one1,7-bis(4-hydroxyphenyl)- hepta-46-dien-3-oneClaisen-Schmidt condensationdiarylheptanoidin situ enaminationsynthesis1,7 bis(3,4 dihydroxyphenyl) hepta 4,6 dien 3 one1,7 bis(4 hydroxyphenyl) hepta 4,6 dien 3 onealnustonenatural productunclassified drugaminationarticleClaisen condensationdeprotection reactiondrug structuredrug synthesisproton nuclear magnetic resonanceArticle3991549156210.1080/003979108025420362-s2.0-67650069189Q3WOS:000264825100005Q3