Orkun Erkilic, TugceBayraktar, Bulent2026-02-282026-02-2820250367-6722https://doi.org/10.18805/IJAR.BF-1904https://hdl.handle.net/20.500.12403/6142Background: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein ( Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.eninfo:eu-repo/semantics/openAccessApelincTnIMoringa oleiferaNesfatin-1RatType 1 Diabetes mellitusVisfatinArticle59110811310.18805/IJAR.BF-19042-s2.0-85216837789Q3WOS:001412804800015Q4