Sahin, Engin2024-10-042024-10-0420200039-79111532-2432https://doi.org/10.1080/00397911.2019.1707226http://hdl.handle.net/20.500.12403/3630Aryl and heteroaryl chiral carbinols are useful precursors in the synthesis of drugs. Lactobacillus paracasei BD87E6, which is obtained from a cereal based fermented beverage, was investigated as whole cell biocatalyst for the bioreduction of different ketones (including aromatic, hetero-aromatic and fused bicyclic ketone) into chiral carbinols, which can be used as a pharmaceutical intermediate. The study shows that bioreduction of aryl, heteroaryl and fused bicyclic ketone (1-5) to their corresponding chiral carbinols (1a-5a) in excellent enantioselectivity (>99%) with high yields. This study gave the first example for an enantiopure production of (S)-6-chlorochroman-4-ol (3a), which has many antioxidant activity, by a biological method. For asymmetric bioreduction of other prochiral ketones, these results open way to use of L. paracasei BD87E6 as biocatalysts. Also, the present process shows a hopeful and alternative green synthesis for the production of enantiopure carbinols in a mild, inexpensive and environmentally friendly process.eninfo:eu-repo/semantics/closedAccessBiotransformationchiral heteroaryl carbinolenantioselective bioreduction(S)-6-chlorochroman-4-olwhole-cell biocatalystArticle50454955710.1080/00397911.2019.17072262-s2.0-85077365610Q3WOS:000504562800001Q3