Tasdemir, VolkanKalay, ErbayDertli, EnesSahin, Engin2024-10-042024-10-0420201024-24221029-2446https://doi.org/10.1080/10242422.2020.1768245http://hdl.handle.net/20.500.12403/3048Aromatic alpha-halohydrins, particularly 2-haloethanols as significant precursor of drugs, can easily be converted to chiral beta-adrenergic receptor blockers. Eight strains of Lactobacillus curvatus were tested as biocatalysts for asymmetric reduction of 2-bromo-1-(naphthalen-2-yl)ethanone 1 to 2-bromo-1- (naphthalen-2-yl) ethanol 2. The parameters of the bioreduction were optimized using L. curvatus N4, the best biocatalyst found. As a result, (R)-2-bromo-1-(naphthalen-2-yl)ethanol 2, which can be beta-adrenergic receptor blocker precursor, was produced for the first time in high yield and enantiomerically pure form using biocatalysts. Moreover, the gram scale synthesis was performed and 7.54 g of (R)-2 was synthesized as enantiopure form (enantiomeric excess >99%) in 48 h. The important advantages of this process are that it produces of (R)-2 for the first time in enantiopure form, in excellent yield and under environmentally friendly and moderate reaction conditions. This system is of the potential to be applied at a commercial scale.eninfo:eu-repo/semantics/closedAccessChiral 2-haloethanolsbiocatalystsasymmetric reduction(R)-2-bromo-1-(naphthalen-2-yl)ethanolLactobacillus curvatusArticle38643844410.1080/10242422.2020.17682452-s2.0-85085629258Q3WOS:000538739900001Q4