Taysi S.Oztasan N.Efe H.Polat M.F.Gumustekin K.Siktar E.Canakci E.Akcay F.Dane S.Gul M.20.04.20192019-04-2020.04.20192019-04-2020080231-424Xhttps://dx.doi.org/10.1556/APhysiol.95.2008.4.2https://hdl.handle.net/20.500.12403/984The aim of this study was to investigate whether an 8-week treadmill training attenuates exerciseinduced oxidative stress in rat liver. Male rats were divided into untrained and trained groups. Endurance training consisted of treadmill running at a speed of 2.1 km/h, 1.5 h/day, 5 days a week for 8 weeks. To see the effects of endurance training on acute exhaustive exercise induced oxidative stress, untrained and trained rats were further devided into two groups: animals killed at rest and those killed after acute exhaustive exercise, in which the rats run at 2.1 km/h (10% uphill) until exhaustion. Acute exhaustive exercise increased malondialdehyde level in untrained but not in trained rats. It decreased the activity of glutathione peroxidase and total (enzymatic plus non-enzymatic) superoxide scavenger activity in untrained rats and catalase activity in trained rats. However, it did not affect glutathione S-transferase, glutathione reductase, superoxide dismutase and non-enzymatic superoxide radical scavenger activities in both trained and untrained rats. On the other hand, endurance training decreased glutathione peroxidase and glutathione S-transferase activities. The results suggested that endurance training attenuated exercise-induced oxidative stress in liver, probably by preventing the decreases in glutathione peroxidase and total superoxide scavenger activities during exercise. © 2008 Akadémiai Kiadó.eninfo:eu-repo/semantics/closedAccessAntioxidant enzymesEndurance trainingExhaustive exerciseMalondialdehydeOxidative stressantioxidantglutathione reductaseglutathione transferasemalonaldehydesuperoxide dismutaseanimalanimal experimentarticleendurancelivermalemetabolismoxidative stressphysiologyratrunningSprague Dawley ratAnimalsAntioxidantsGlutathione ReductaseGlutathione TransferaseLiverMaleMalondialdehydeOxidative StressPhysical Conditioning, AnimalPhysical EnduranceRatsRats, Sprague-DawleyRunningSuperoxide DismutaseAntioxidant enzymesEndurance trainingExhaustive exerciseMalondialdehydeOxidative stressantioxidantglutathione reductaseglutathione transferasemalonaldehydesuperoxide dismutaseanimalanimal experimentarticleendurancelivermalemetabolismoxidative stressphysiologyratrunningSprague Dawley ratAnimalsAntioxidantsGlutathione ReductaseGlutathione TransferaseLiverMaleMalondialdehydeOxidative StressPhysical Conditioning, AnimalPhysical EnduranceRatsRats, Sprague-DawleyRunningSuperoxide DismutaseArticle95433734710.1556/APhysiol.95.2008.4.2