Kandemir, Hakanİzgi, SametCınar, IrfanCebeci, FatmaDırıcan, EbubekirSaglam, Mehmet F.Sengul, Ibrahim Fazil2026-02-282026-02-2820230022152Xhttps://doi.org/10.1002/jhet.4562https://hdl.handle.net/20.500.12403/5724Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells. © 2022 Wiley Periodicals LLC.eninfo:eu-repo/semantics/closedAccess2 3 diphenyl indole2 3 phenyl dimethoxyindole derivative3 diphenyl 4 6 dimethoxyindole derivative3 phenyl indole7 (hydrazonomethyl) 4 6 dimethoxy 2 3 diphenyl 1h indole7 (hydrazonomethyl) 4 6 dimethoxy 3 phenyl 1h indolehydrazide derivativeindole 7 carbohydrazide derivativeindole derivativeindometacinmelatoninn ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydraziden ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 methylbenzohydraziden ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene) 4 nitrobenzohydraziden ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)acetohydraziden ([4 6 dimethoxy 2 3 diphenyl 1h indol 7 yl]methylene)benzohydraziden ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 3 (trifluoromethyl)benzohydraziden ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene) 4 nitrobenzohydraziden ([4 6 dimethoxy 3 phenyl 1h indol 7 yl]methylene)acetohydrazideoxypertineunclassified drugABTS radical scavenging assayantineoplastic activityantioxidant activityArticlebreast adenocarcinoma cell linecarbon nuclear magnetic resonancecell proliferationcell viabilitycontrolled studycytotoxicityDPPH radical scavenging assaydrug synthesisfemaleFourier transform infrared spectroscopygastric adenocarcinoma cell linehumanmass spectrometryneuroblastoma cell lineproton nuclear magnetic resonanceX ray diffractionArticle601748510.1002/jhet.45622-s2.0-85137568357Q2