Kizil H.E.Ceker S.Capik O.Agar G.20.04.20192019-04-2020.04.20192019-04-2020181391-4588https://dx.doi.org/10.4038/jnsfsr.v46i2.8423https://hdl.handle.net/20.500.12403/438Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 ?gmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 ?gmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid. © 2018, National Science Foundation. All rights reserved.eninfo:eu-repo/semantics/openAccessAntigenotoxic activityComet assayDiffractaic acidLecanoric acidLichen compoundsLobaric acidVulpinic acidAntigenotoxic activityComet assayDiffractaic acidLecanoric acidLichen compoundsLobaric acidVulpinic acidArticle46222723110.4038/jnsfsr.v46i2.84232-s2.0-85049533989Q3WOS:000438990400013Q4