Show simple item record

dc.contributor.authorÖksüz S.
dc.contributor.authorŞahin E.
dc.contributor.authorDertli E.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:04Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:04Z
dc.date.issued2018
dc.identifier.issn1612-1872
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.201800028
dc.identifier.urihttps://hdl.handle.net/20.500.12403/376
dc.description.abstractGlobal sales of single enantiomeric drug products are growing at an alarming rate every year. A total of 7 bacterial strains were screened for their ability to reduce acetophenones to its corresponding alcohol. Among these strains Lactobacillus paracasei BD87E6 was found to be the most successful biocatalyst to reduce the ketones to the corresponding alcohols. The reaction conditions were systematically optimized for the reducing agent Lactobacillus paracasei BD87E6, which showed high enantioselectivity and conversion for the bioreduction. The preparative scale asymmetric reduction of 3-methoxyacetophenone (1h) by Lactobacillus paracasei BD87E6 gave (R)-1-(3-methoxyphenyl)ethanol (2h) with 92% yield and 99% enantiomeric excess. Compound 2h could be used for the synthesis of (S)-rivastigmine which has a great potential for the treatment of Alzheimer's disease. This study demonstrates that Lactobacillus paracasei BD87E6 can be used as a biocatalyst to obtain chiral carbinol with excellent yield and selectivity. The whole cell catalyzed the reductions of ketone substrates on the preparative scale, demonstrating that Lactobacillus paracasei BD87E6 would be a valuable biocatalyst for the preparation of chiral aromatic alcohols of pharmaceutical interest. © 2018 Wiley-VHCA AG, Zurich, Switzerlanden_US
dc.language.isoengen_US
dc.publisherWiley-VCH Verlag
dc.relation.isversionof10.1002/cbdv.201800028
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasymmetric synthesis
dc.subjectbiocatalysis
dc.subjectchirality
dc.subjectdrug precursor
dc.subjectLactobacillus paracasei
dc.subject1 phenylethanol
dc.subjectacetophenone
dc.subjectacetophenone derivative
dc.subjectrivastigmine
dc.subjectmethanol
dc.subjectArticle
dc.subjectbiocatalyst
dc.subjectcatalysis
dc.subjectchemical reaction
dc.subjectchirality
dc.subjectenantioselectivity
dc.subjecthigh performance liquid chromatography
dc.subjectincubation time
dc.subjectLactobacillus paracasei
dc.subjectnonhuman
dc.subjectpH
dc.subjectreaction analysis
dc.subjectreduction (chemistry)
dc.subjectshear stress
dc.subjectsubstrate concentration
dc.subjectsynthesis
dc.subjecttemperature sensitivity
dc.subjectthin layer chromatography
dc.subjectwhole cell
dc.subjectbiocatalysis
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectcytology
dc.subjectLactobacillus paracasei
dc.subjectmetabolism
dc.subjectoxidation reduction reaction
dc.subjectstereoisomerism
dc.subjectBiocatalysis
dc.subjectLactobacillus paracasei
dc.subjectMethanol
dc.subjectMolecular Structure
dc.subjectOxidation-Reduction
dc.subjectRivastigmine
dc.subjectStereoisomerism
dc.subjectasymmetric synthesis
dc.subjectbiocatalysis
dc.subjectchirality
dc.subjectdrug precursor
dc.subjectLactobacillus paracasei
dc.subject1 phenylethanol
dc.subjectacetophenone
dc.subjectacetophenone derivative
dc.subjectrivastigmine
dc.subjectmethanol
dc.subjectArticle
dc.subjectbiocatalyst
dc.subjectcatalysis
dc.subjectchemical reaction
dc.subjectchirality
dc.subjectenantioselectivity
dc.subjecthigh performance liquid chromatography
dc.subjectincubation time
dc.subjectLactobacillus paracasei
dc.subjectnonhuman
dc.subjectpH
dc.subjectreaction analysis
dc.subjectreduction (chemistry)
dc.subjectshear stress
dc.subjectsubstrate concentration
dc.subjectsynthesis
dc.subjecttemperature sensitivity
dc.subjectthin layer chromatography
dc.subjectwhole cell
dc.subjectbiocatalysis
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectcytology
dc.subjectLactobacillus paracasei
dc.subjectmetabolism
dc.subjectoxidation reduction reaction
dc.subjectstereoisomerism
dc.subjectBiocatalysis
dc.subjectLactobacillus paracasei
dc.subjectMethanol
dc.subjectMolecular Structure
dc.subjectOxidation-Reduction
dc.subjectRivastigmine
dc.subjectStereoisomerism
dc.titleSynthesis of Enantiomerically Enriched Drug Precursors by Lactobacillus paracasei BD87E6 as a Biocatalysten_US
dc.typearticleen_US
dc.relation.journalChemistry and Biodiversityen_US
dc.contributor.departmentBayburt Universityen_US
dc.contributor.authorID57202216168
dc.contributor.authorID37098938400
dc.contributor.authorID36815706500
dc.identifier.volume15
dc.identifier.issue6
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record