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The anti-genotoxic effect of some lichenic acids

dc.contributor.authorKizil H.E.
dc.contributor.authorCeker S.
dc.contributor.authorCapik O.
dc.contributor.authorAgar G.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:11Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:11Z
dc.date.issued2018
dc.identifier.issn1391-4588
dc.identifier.urihttps://dx.doi.org/10.4038/jnsfsr.v46i2.8423
dc.identifier.urihttps://hdl.handle.net/20.500.12403/438
dc.description.abstractFour lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 ?gmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 ?gmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid. © 2018, National Science Foundation. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherNational Science Foundation
dc.relation.isversionof10.4038/jnsfsr.v46i2.8423
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntigenotoxic activity
dc.subjectComet assay
dc.subjectDiffractaic acid
dc.subjectLecanoric acid
dc.subjectLichen compounds
dc.subjectLobaric acid
dc.subjectVulpinic acid
dc.subjectAntigenotoxic activity
dc.subjectComet assay
dc.subjectDiffractaic acid
dc.subjectLecanoric acid
dc.subjectLichen compounds
dc.subjectLobaric acid
dc.subjectVulpinic acid
dc.titleThe anti-genotoxic effect of some lichenic acidsen_US
dc.typearticleen_US
dc.relation.journalJournal of the National Science Foundation of Sri Lankaen_US
dc.contributor.departmentBayburt Universityen_US
dc.contributor.authorID55771966200
dc.contributor.authorID53983736200
dc.contributor.authorID57202830045
dc.contributor.authorID7003921401
dc.identifier.volume46
dc.identifier.issue2
dc.identifier.startpage227
dc.identifier.endpage231
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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