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Mechanism of capsaicin inhibition of aldose reductase activity

dc.contributor.authorAlim Z.
dc.contributor.authorKilinc N.
dc.contributor.authorSengul B.
dc.contributor.authorBeydemir S.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:18Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:18Z
dc.date.issued2017
dc.identifier.issn1095-6670
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.21898
dc.identifier.urihttps://hdl.handle.net/20.500.12403/489
dc.description.abstractAldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway. © 2017 Wiley Periodicals, Inc.en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sons Inc.
dc.relation.isversionof10.1002/jbt.21898
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaldose reductase
dc.subjectcapsaicin
dc.subjectdiabetic complications
dc.subjectinhibition
dc.subjectaldehyde reductase
dc.subjectcapsaicin
dc.subjectaldehyde reductase
dc.subjectcapsaicin
dc.subjectenzyme inhibitor
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectheart
dc.subjectin vitro study
dc.subjectkidney
dc.subjectliver
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectanimal
dc.subjectantagonists and inhibitors
dc.subjectantibody specificity
dc.subjectdose response
dc.subjectmetabolism
dc.subjectSprague Dawley rat
dc.subjectAldehyde Reductase
dc.subjectAnimals
dc.subjectCapsaicin
dc.subjectDose-Response Relationship, Drug
dc.subjectEnzyme Inhibitors
dc.subjectMale
dc.subjectOrgan Specificity
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectaldose reductase
dc.subjectcapsaicin
dc.subjectdiabetic complications
dc.subjectinhibition
dc.subjectaldehyde reductase
dc.subjectcapsaicin
dc.subjectaldehyde reductase
dc.subjectcapsaicin
dc.subjectenzyme inhibitor
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectheart
dc.subjectin vitro study
dc.subjectkidney
dc.subjectliver
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectanimal
dc.subjectantagonists and inhibitors
dc.subjectantibody specificity
dc.subjectdose response
dc.subjectmetabolism
dc.subjectSprague Dawley rat
dc.subjectAldehyde Reductase
dc.subjectAnimals
dc.subjectCapsaicin
dc.subjectDose-Response Relationship, Drug
dc.subjectEnzyme Inhibitors
dc.subjectMale
dc.subjectOrgan Specificity
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.titleMechanism of capsaicin inhibition of aldose reductase activityen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBayburt Universityen_US
dc.contributor.authorID23391844000
dc.contributor.authorID56406261600
dc.contributor.authorID56711195000
dc.contributor.authorID6603903192
dc.identifier.volume31
dc.identifier.issue7
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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