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Human serum paraoxonase-1 (hPON1): In vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium

dc.contributor.authorTürkeş C.
dc.contributor.authorSöyüt H.
dc.contributor.authorBeydemir Ş.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:43:48Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:43:48Z
dc.date.issued2015
dc.identifier.issn1475-6366
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2014.959511
dc.identifier.urihttps://hdl.handle.net/20.500.12403/684
dc.description.abstractIn this study, we investigated the effects of antibacterial drugs (moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium) on human serum paraoxonase-1 (hPON1) enzyme activity from human serum in vitro conditions. For this purpose, hPON1 enzyme was purified from human serum using simple chromatographic methods. The antibacterial drugs exhibited inhibitory effects on hPON1 at low concentrations. K<inf>i</inf> constants were calculated to be 2.641 ± 0.040 mM, 5.525 ± 0.817 mM, 35.092 ± 1.093 mM, 252.762 ± 5.749 mM and 499.244 ± 10.149 mM, respectively. The inhibition mechanism of moxifloxacin hydrochloride was competitive, whereas levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium were noncompetitive inhibitors. © 2014 Informa UK Ltd. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltd
dc.relation.isversionof10.3109/14756366.2014.959511
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCefepime hydrochloride
dc.subjectcefotaxime sodium
dc.subjectceftizoxime sodium
dc.subjectinhibition
dc.subjectlevofloxacin hemihidrate
dc.subjectmoxifloxacin hydrochloride
dc.subjectparaoxonase
dc.subjectaryldialkylphosphatase 1
dc.subjectcefepime
dc.subjectcefotaxime
dc.subjectceftizoxime
dc.subjectlevofloxacin
dc.subjectmoxifloxacin
dc.subjectaryldialkylphosphatase
dc.subjectcefepime
dc.subjectcefotaxime
dc.subjectceftizoxime
dc.subjectcephalosporin derivative
dc.subjectlevofloxacin
dc.subjectmoxifloxacin
dc.subjectPON1 protein, human
dc.subjectquinolone derivative
dc.subjectanion exchange chromatography
dc.subjectArticle
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectgel filtration chromatography
dc.subjectin vitro study
dc.subjectprecipitation
dc.subjectpriority journal
dc.subjectserum
dc.subjectantagonists and inhibitors
dc.subjectblood
dc.subjecthuman
dc.subjectAryldialkylphosphatase
dc.subjectCefotaxime
dc.subjectCeftizoxime
dc.subjectCephalosporins
dc.subjectFluoroquinolones
dc.subjectHumans
dc.subjectIn Vitro Techniques
dc.subjectLevofloxacin
dc.subjectCefepime hydrochloride
dc.subjectcefotaxime sodium
dc.subjectceftizoxime sodium
dc.subjectinhibition
dc.subjectlevofloxacin hemihidrate
dc.subjectmoxifloxacin hydrochloride
dc.subjectparaoxonase
dc.subjectaryldialkylphosphatase 1
dc.subjectcefepime
dc.subjectcefotaxime
dc.subjectceftizoxime
dc.subjectlevofloxacin
dc.subjectmoxifloxacin
dc.subjectaryldialkylphosphatase
dc.subjectcefepime
dc.subjectcefotaxime
dc.subjectceftizoxime
dc.subjectcephalosporin derivative
dc.subjectlevofloxacin
dc.subjectmoxifloxacin
dc.subjectPON1 protein, human
dc.subjectquinolone derivative
dc.subjectanion exchange chromatography
dc.subjectArticle
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectgel filtration chromatography
dc.subjectin vitro study
dc.subjectprecipitation
dc.subjectpriority journal
dc.subjectserum
dc.subjectantagonists and inhibitors
dc.subjectblood
dc.subjecthuman
dc.subjectAryldialkylphosphatase
dc.subjectCefotaxime
dc.subjectCeftizoxime
dc.subjectCephalosporins
dc.subjectFluoroquinolones
dc.subjectHumans
dc.subjectIn Vitro Techniques
dc.subjectLevofloxacin
dc.titleHuman serum paraoxonase-1 (hPON1): In vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodiumen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentBayburt Universityen_US
dc.contributor.authorID55857860900
dc.contributor.authorID23502381000
dc.contributor.authorID6603903192
dc.identifier.volume30
dc.identifier.issue4
dc.identifier.startpage622
dc.identifier.endpage628
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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