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dc.contributor.authorSöyüt H.
dc.contributor.authorKaya E.D.
dc.contributor.authorBeydemir S.
dc.date.accessioned20.04.201910:49:12
dc.date.accessioned2019-04-20T21:44:15Z
dc.date.available20.04.201910:49:12
dc.date.available2019-04-20T21:44:15Z
dc.date.issued2014
dc.identifier.issn2221-1691
dc.identifier.urihttps://dx.doi.org/10.12980/APJTB.4.2014APJTB-2014-0059
dc.identifier.urihttps://hdl.handle.net/20.500.12403/809
dc.description.abstractObjective: To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1). Methods: hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography. Results: The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive. Conclusions: Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro. © 2014 by the Asian Pacific Journal of Tropical Biomedicine.en_US
dc.language.isoengen_US
dc.publisherAsian Pacific Tropical Biomedicine Press
dc.relation.isversionof10.12980/APJTB.4.2014APJTB-2014-0059
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCefoperazone sodium
dc.subjectInhibition
dc.subjectMeropenem trihydrate
dc.subjectParaoxonase
dc.subjectPiperacillin sodium
dc.subjectaryldialkylphosphatase 1
dc.subjectcefoperazone
dc.subjectmeropenem
dc.subjectpiperacillin
dc.subjectanion exchange chromatography
dc.subjectArticle
dc.subjectbinding affinity
dc.subjectcompetitive inhibition
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdrug protein binding
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectenzyme purification
dc.subjectgel filtration chromatography
dc.subjecthuman
dc.subjectIC50
dc.subjectin vitro study
dc.subjectCefoperazone sodium
dc.subjectInhibition
dc.subjectMeropenem trihydrate
dc.subjectParaoxonase
dc.subjectPiperacillin sodium
dc.subjectaryldialkylphosphatase 1
dc.subjectcefoperazone
dc.subjectmeropenem
dc.subjectpiperacillin
dc.subjectanion exchange chromatography
dc.subjectArticle
dc.subjectbinding affinity
dc.subjectcompetitive inhibition
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdrug protein binding
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjectenzyme purification
dc.subjectgel filtration chromatography
dc.subjecthuman
dc.subjectIC50
dc.subjectin vitro study
dc.titleImpact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: An in vitro studyen_US
dc.typearticleen_US
dc.relation.journalAsian Pacific Journal of Tropical Biomedicineen_US
dc.contributor.departmentBayburt Universityen_US
dc.contributor.authorID23502381000
dc.contributor.authorID55537752500
dc.contributor.authorID6603903192
dc.identifier.volume4
dc.identifier.issue8
dc.identifier.startpage603
dc.identifier.endpage609
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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