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    Antiproliferative and apoptotic effects of diffractaic acid in A549 and AGS cancer cells
    (American Institute of Physics Inc., 2017) Kızıl, Hamit Emre; Ağar, Güleray
    In this study, we determined the antiproliferative and apoptotic effects of diffractaic acid by measuring the gene expression changes of topo II ?, caspase-3 and p53 on A549 and AGS cancer cells. Real time PCR assay was used to measure the change folds. It was determined that concentrations of 12,5, 50 and 100?g / ml were antiproliferative and apoptotic for the A549 cancer cell line and 50?g / ml for the AGS cell line. © 2017 Author(s).
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    Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases
    (2020) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Ağar, Güleray; Sarı, Nurşen
    In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a twostage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-inducedantimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN)methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce themutagenicity caused by sodium azide (NaN3) which is used as a positive control.
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    Synthesis of novel polymers containing Schiff base as potential antimutagenic and antimicrobial agents
    (Sami Publishing Company, 2020) Nartop, Dilek; Tokmak, Erkan; Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Öğütcü, Hatice; Ağar, Güleray; Allı, Sema
    In this research study, two novel polymers including Schiff base were prepared by condensation reaction of polystyrene-A-NH2 with 5-nitro-2-thiophenecarboxaldehyde/or 5-(2-nitrophenyl)-2-furancarboxaldehyde. The synthesized polymers were evaluated using the elemental analysis, infrared spectroscopy (IR), gel permeation chromatography (GPC), thermal gravimetric analysis (TG/DTA). In addition, the antimicrobial and antimutagenic study of the polymers were reported. The antibacterial and antifungal activity were investigated using the diffusion method against pathogenic bacterial strains. PA-TC and PA-FC polymers exhibited the highest antimicrobial activity against the S. typhi H. and P. vulgaris, respectively. PA-FC polymer revealed the highest antifungal activity against C. albicans. The antimutagenic effects were evaluated using the sister chromatid exchange (SCE) and micronucleus (MN) methods against the sodium azide (NaN3) in human lymphocyte cells. The results demonstrated that the PA-FC polymer have strong antimutagenic properties, especially in the concentration of 20 µg/mL. © 2020 by SPC (Sami Publishing Company)