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    ANTIBACTERIAL, ANTIFUNGAL, ANTIBIOFILM, ANTIOXIDANT, AND ANTICANCER PROPERTIES OF METHANOL EXTRACTS OF SOME ACANTHOLIMON BOISS (PLUMBAGINACEAE) SPECIES
    (2023) Bostancı, Maside Temiz; Bülbül, Ali Savaş; Uygun, Cihangir; Bekmezci, Muhammed; Bayat, Ramazan; Şen, Fatih
    Therapeutic properties of plants have been used since the existence of mankind. To benefit from this feature, the discovery of the active components of plants has gained momentum today. One of these plant species is Acantholimon Boiss. This plant extract has antifungal, antimicrobial, and anticancer properties. In this article, antimicrobial, antifungal and antioxidant capacities and antibiofilm properties of Acantholimon Boiss plant extract on 15 bacterial and 2 fungal species were evaluated. Antimicrobial properties were evaluated by Agar Well Diffusion method. It was observed that the plants formed a zone diameter of 12-18 cm. Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests were used to determine the minimum active property. Biofilms of almost all bacteria were reduced by 10-50% by Acantholimon species at doses of 8 mg/ml-16 mg/ml. For MCF-7 cells, the IC50 values for A. acerosum subsp. brachystachyum (Boiss. ), A. acenum var. balansae, A. armenum var. balansae and A. kotschyi were 0.143 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml and 0.107 mg/ml, respectively. The same doses did not show a cytotoxic effect on HUVEC cell lines. With this article, it has given important results in terms of having a wide range of bacterial studies and examining its activities in fungi and cell lines. These findings suggest that extracts of Acantholimon Boiss species may be a potential source of natural medicines and antibacterial, antifungal, antibiofilm, antioxidant, and anticancer activities may support their therapeutic use.
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    Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance
    (Pergamon-Elsevier Science Ltd, 2022) Bostanci, Maside Temiz; Bulbul, Ali Savas; Celik, Ibrahim Seyfettin; Kocabas, Yusuf Ziya; Burhan, Hakan; Bayat, Ramazan; Sen, Fatih
    In this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 bacteria and 2 fungi of Salvia marashica Ilcim, Celep & Dogan and Salvia caespitosa Montbret & Aucher ex Benth species were performed by Agar Well Diffusion and Microdilution methods. Salvia species showed sensitivity with a zone diameter of 12-16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the dilution method were used to determine the Minimum inhibited concentration (MIC) and Minimum bactericidal concentration (MBK). The MIC values of the plants are mostly 0.5 mg/ml- 4 mg/ml and MBC values are between 0.5 mg/ml- 8 mg/ml. Antifungal activity findings are remarkable on the species and it has been observed to have very high effects especially on Candida parapsilosis. When the antioxidant research findings are examined; It was observed that Salvia marashica and Salvia caespitosa plants have approximately 75% antioxidant activity at 1 mg/ml, and findings mostly directly proportional be- tween concentrations and antioxidant activity capacity were recorded. MCF-7 and HUVEC cell lines were used to investigate anticancer activity properties. In line with the findings, while the IC50 value of Salvia marashica on the MCF-7 Cell line was 0.125 mg/ml, it was 1.65 mg/ml in the HUVEC cell line, while the IC50 value of Salvia caespitosa on the MCF-7 Cell line was 0.115 mg/ml in the HUVEC Cell line. It was found to be 9.87 mg/ml. It has been proven that both Salvia species have a cytotoxic effect on the MCF-7 Cell line.