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    Levels of Knowledge of Protection From Infectious Infections, Particularly Covid, of Medical Worker Prospective Students
    (AVES, 2023) Ateş, Fatih Mehmet; Albayrak, Mevlüt; Bayir, Yasin
    Objective: With this research, it was aimed to determine the knowledge level of health worker candidate students about protection from infectious infections, especially COVID. Methods: The sample of the study consisted of a university students from Vocational School of Health Services and Faculty of Pharmacy. The research data were collected by applying the 49-question “Knowledge Levels Questionnaire for Healthcare Professional Candidate Students on Protection from Communicable Infections, Especially COVID” and the “Sociodemographic Information Form” consisting of 7 questions. Data; number, percentile, mean and standard devia-tion, and chi-square test. Results: 3.16% of the students had operating room services, 2.69% dental prosthesis technology, 9.13% dialysis, 10.54% pharmacy services, 4.92% physiotherapy, 4.92% first and emergency aid, 4.92% audiometry, 7.85% orthopedic prosthetics and orthotics, 4.10% medical documentation and secretarial, 7.96% medical imaging techniques, 13.82% were studying in medical laboratory tech-niques, 3.40% in elderly care, 22.60% in pharmacy and 60.77% was determined to be a first year student. 97.9% of the undergraduate students in the Faculty of Pharmacy compared to the students in other departments knew the necessity of paying attention to personal hygiene in order to be protected from infectious diseases, and the difference was statistically significant p <,05. Conclusion: Course contents should be enriched with digital materials to raise awareness against infectious diseases. © 2023, AVES. All rights reserved.
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    POSITIVE EFFECTS OF OXYRESVERATROL ON OXIDATIVE STRESS DAMAGE IN L929 FIBROBLAST CELLS
    (University of Ankara, 2023) Ateş, Fatih Mehmet; Bayir, Yasin
    Objective: It was aimed to determine the regenerative effect of oxyresveratrol in eliminating the cell damage caused by the effect of H2O2 in L929 fibroblast cells. Material and Method: Total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), total phenolic substance levels of oxyresveratrol were measured at different concentrations. After the IC50 value of oxyresveratrol fibroblast cells was determined by the MTT method, the regenerative effect on oxidative stress damage induced by H2O2 at 12.5-400 µM concentrations was performed with the xCELLigence device to measure cell proliferation in-vitro. In addition, scratch analysis was performed at concentrations of 3.125-25 µM in order to determine the wound healing levels in cell damage. Result and Discussion: The TAC value of oxyresveratrol at 0.5 mg/ml was 3 ± 0.3 and the TOC value was 0.77 ± 0.52; (OSI) value was found to be 0.02 ± 0.09. It has been observed that the total phenolic substance (TPS) concentrations of oxiresveratrol at different doses from 0.625 mg/ml to 10 mg/ml have higher TPS from low concentration to high concentration. Oxyresveratrol L929 fibroblast cells IC50 value 214.2 ?M; The IC50 value of oxyresveratrol was determined to be 109.7 ?M in the cell line of L929 fibroblast cells exposed to H2O2. The highest cell proliferation was observed when measuring the 12.5 ?M concentration of oxiresveratrol with the xCELLigence device. Scratch analysis showed a greater improvement than other doses, with a cell proliferation of 62% at the 24th hour and 88% at the 48th hour at a concentration of 12.5 ?M oxyresveratrol in H2O2-damaged cells. The 12.5 ?M concentration was determined to be the most effective concentration in both proliferation and scratch analysis. Oxyresveratrol; with its antioxidant capacity at low concentrations, L929 protects fibroblast cells from oxidative stress in cellular damage caused by H2O2, and creates a power multiplier effect on fibroblast viability and migration. These results indicate that oxyresveratrol; showed that it can be effective at the cellular level preventing of acute or chronic diseases caused by free oxygen radicals. It can be thought that oxyresveratrol may be a potential molecule in the treatment of oxidative stress-induced diseases with more comprehensive studies to be carried out at the cellular level and in-vivo studies. © 2023 University of Ankara. All rights reserved.