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Öğe Effect of Different Rates of Rambutan Peel Extract on Visfatin and Cardiac Troponi N I Response in Type 2 Diabetic Rats Induced with Streptozotocin(Agricultural Research Communication Centre, 2024) Tasci, S. celikel; Bayraktar, B.; Bulbul, A. S.; Sait, A.; Korkmaz, S.Background: The aim of this study was to investigate the effects of STZ (Streptozotocin) and Rambutan peel extract (RPE) on serum visfatin and cardiac response in experimental Type 2 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were randomly selected, each containing 8 rats as Control (C), R100 (RPE 100 mg/kg group given with oral gavage route of administration (OGRA), R200 (RPE 200 mg/kg group given with OGRA), R300 (RPE 300 mg/kg group given with OGRA); Diabetes Control (DC): STZ 50 mg/kg i.p administered group, DR100 (D+100 mg/kg JPE), DR200 (D+200 mg/kg JPE), DR300 (D+300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (vena caudalis) of all subjects on days 0 and 21 of the study. Visfatin and cTnI levels in the serum samples were measured and evaluated by ELISA method. Result: While the increase in mean serum visfatin and cTnI levels in diabetic groups was seen mostly in DC groups, the most significant decrease in mean serum visfatin level due to the addition of RPE was determined in DR100 groups (p<0.01). As a result, it was concluded that the administration of 100 mg/kg RPE in rats had no adverse effects. It was concluded that RPE, which has a cardioprotective effect by regulating the visfatin response that plays a role in the development of diabetes, may be useful in supporting the impaired cardiovascular system function that occurs in diabetes.Öğe Effect of Graviola Oil Extract on Anti-obesity Effect and Adipokine (Apelin and Adiponectin) Response in High Fat Diet-induced Obese Rats(Agricultural Research Communication Centre, 2025) Erkilic, T. Orkun; Bayraktar, B.Background: This study aims to investigate the anti-obesity effect of GOE with adipokine (apelin and adiponectin) response at different doses (100 and 200 mg/kg) of GOE in normal healthy and obese rats with High-fat diet (HF). Methods: In this study, 36 adult male Wistar albino rats, aged between 8-10 weeks, were used. 6 groups were created, with 6 rats in each group: Control (C), Rat group without GOE and HF application, G100 (GOE 100 mg/kg group given with oral gavage route of administration (OGRA), G200 (GOE 200 mg/kg group given with OGRA), HFC (HF control group): no HF and no GOE group), HF100 (rats receiving HF were 100 mg/kg graviola oil extract added to their diet), HF200 (rats receiving HF were 200 mg/kg graviola oil extract added to their diet). Blood samples were taken from the tail vein (vena caudalis) of all on days 0 and 60 of the study. Apelin and adiponectin levels in the serum samples were measured by ELISA method. Result: In the present study, a significant increase (p<0.01) was observed in the mean serum apelin level in the HF groups at the end of the 60 day after HF induction, while a significant decrease (p<0.01) was also detected in the adiponectin level. On the other hand, when examined in terms of BW, the most significant decrease due to GOE addition in the HF groups, i.e. the anti-obesity effect, was determined in the HFG200 mg/kg group (p<0.01). As a result, it was concluded that GOE may be safe and beneficial when administered at a dose of 200 mg/kg in obesity-induced rats.Öğe Effect of Jackfruıt Pulp Extract on Serum Nesfatın-1 and Vısfatın Levels in Streptozotocın-induced Rats(Agricultural Research Communication Centre, 2025) Erkilic, T. Orkun; Bayraktar, B.Background: The aim of this study was to investigate the effects of different amounts of jackfruit pulp extract (JPE) in the diets on serum nesfatin-1 and visfatin levels in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. 8 groups were created, with 8 rats in each group: Control (C), J100 (JPE 100 mg/kg group given with oral gavage route of administration (OGRA), J200 (JPE 200 mg/kg group given with OGRA), J300 (JPE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, DJ100 (D+100 mg/kg JPE), DJ200 (D + 200 mg/kg JPE), DJ300 (D). + 300 mg/kg JPE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein (Vena caudalis) of all subjects on days 0 and 21 of the study. Nesfatin-1 and visfatin levels in the serum samples were measured by ELISA method. Result: As a result, in the diabetes groups of our study, the most significant increase in the mean serum nesfatin-1 level and the most significant decrease in the mean serum visfatin level occurred in the DJ200 groups at the end of the 21st day due to the addition of JPE (p<0.05). As a result, it was concluded that JPE may be safe and beneficial when administered at a dose of 200 mg/kg in diabetic groups.Öğe Effects of Varying Essential Oil Mixture Concentrations Applied Underconditions of Different Temperature Stress on Cardiac Markers and Other Blood Parameters(Facta-Fundacio Arnco Ciencia Tecnologia Avicolas, 2019) Bayraktar, B.; Tekce, E.Cardiac troponin (cTnI) and erythrocyte distribution width (RDW) have been used as specific markers for the evaluation of cardiac arrhythmias and myocardial diseases. In this experimental study, we aimed to determine the dose-dependent administration of an Essential OilMixture (EOM) (Eucalyptus globulusLabill, Thymus vulgaris, Cymbopogon nardus, and Syzygiumaromaticum) on the serum erythrocyte indices and myocardial damage. We used 400 male, one-day-old, Ross-308 chicks. Each group ((n=8) (22 degrees C Control (C), C+250 mL/1,000 L, C+500 mL/1,000 L, C+750 mL/1,000 L), 36 degrees C (stress control (SC), SC+250 mL/1,000 L, SC+500 mL/1,000 L, SC+750 mL/1,000 L) was further divided into eight groups with 50 animals. Each group of 50 chicks was further subdivided into five groups with 10 animals in each compartment. The results showed that the WBC, RBC, HGB, HCT, RDW-SD, RDW-CV, and Lymphocyte decreased in groups without exposure to temperature stress (22 degrees C) compared to the 22 degrees C control group; whereas, CnTnI, MCHC, NEUT, and IG (p<0.05) increased compared to the control group. In groups exposed to temperature stress (3 degrees C), the WBC, HGB, HCT, RDW-SD, and Lymphocyte decreased compared to the control group, but MCH, MCHC, NEUT, and IG increased compared to the control. However, cTnI, CK, creatinine, RBC, and RDW had no effect on CD, MONO, EO, and BASO (p<0.05). EOM mixture had no effect on hematological and biochemical parameters.Öğe Investigation of Microbiological, Physiological and Histopathological Changes in Polymicrobial I nfection in Old Rats(Agricultural Research Communication Centre, 2024) Ulker, U.; Kizil, S.; Bayraktar, B.; Alcigir, M. E.; Kul, O.; Kaya, H.; Urusan, H.Background: The aim of this study is to examine the microbiological, clinical, physiological and pathological findings of natural polymicrobial infection developing in a wistar rat colony under long-term observation. Methods: In this study, 70 male Wistar albino rats, 3 years old, raised by conventional methods and housed in a cage environment were used. Thirteen rats with clinical symptoms such as torticollis and rotation were sacrificed for microbiological and histopathological examination after 14 days. For microbiological examination, the rapid diagnostic kit BBL Crystal system was used to identify bacterial agents in tissue and stool samples and the traditional culture method was used for isolation. Result: As a result of microbiological analysis, the rarely isolated Staphylococcus capitis ( S. capitis ) was isolated. Different Staphylococcus spp. It has been determined that the species can cause suppurative meningoencephalitis as well as septicemia in the brains of experimental animals., it is thought that polymicrobial infection will be useful for the identification of bacterial agents and infection prevention and treatment strategies.Öğe Investigation of the relationship between apelin hormone response and some physiological parameters in enzootic bovine leukosis virus infected cattle(Hellenic Veterinary Medical Soc, 2025) Sait, A.; Bayraktar, B.; Korkmaz, S.; Genc, M.; Bayraktar, S.; Kotan, G. C.; Odabasi, M.Apelin is a hormone with lymphangiogenesis potential, associated with tumor growth and lymph node metastasis, and is reported to stimulate tumor vascularization. This study aimed to investigate the response of the apelin hormone in cattle with and without Enzootic Bovine Leukosis (EBL) infection, based on physiological parameters such as breed, age, and body condition score (BCS). A total of 120 Simmental and Montafon cattle of varying ages (<2, 2-8, and >8) and BCS categories (<2, 3-3.5, and >= 4) were included in the study. Serum apelin hormone levels were measured using the ELISA technique in blood samples collected from the neck vein ( Vena jugularis) of the animals. The analysis of mean serum apelin (ng/mL) values revealed that, among EBL-positive cattle, the highest value was 2.77 ng/mL in Simmental cattle aged 2-8 years with a BCS of 3-3.5, while a value of 2.69 ng/mL was observed in Montafon cattle aged >8 years with a BCS of 3-3.5. For EBL-negative cattle, the highest mean serum apelin value was 2.24 ng/mL, recorded in Simmental cattle aged 2-8 years with a BCS of 3-3.5, whereas it was 1.45 ng/mL in Montafon cattle aged >8 years with the same BCS. In conclusion, this study demonstrated for the first time the effect of apelin hormone levels in cattle with or without EBL, depending on physiological parameters such as age, breed, and BCS. It is suggested that the apelin hormone, which is involved in neoplastic lymphocyte cell infiltration in the lymphoreticular tissues of cattle, and plays a role in regulating tumor growth in EBL, a malignant tumor disease, may contribute to eradication programs. Moreover, the evaluated parameters may prove valuable for disease prevention and control strategies.Öğe Investigation of the relationship of apelin hormone response with some physiological parameters in Maedi-Visna infected sheep(Hellenic Veterinary Medical Soc, 2020) Bayraktar, B.; Sait, A.; Takma, C.; Tekce, E.In this study, the objective was to assess the serological characteristics of sheep, during lactation and pregnancy periods, and rams belonging to the Red Karaman and White Karaman-Kangal race infected with maedi-visna infection and body condition score (BCS) of <= 2, 3- 3.5 and >= 4 (high) and to analyse the relationship between the level of apelin and its secretion. Apelin level in the blood serum samples obtained from the jugular veinof the sheeps was determined using ELISA method. As a result of the analyses, it was determined that the level of apelin was statistically different between the races; between lactating sheep and pregnant sheep; and sheep and rams. There was no difference between the BCS groups (p > 0.05). Race and sex interaction as well as race, sex and BCS triple interaction effects were found significant (p < 0.05). It was observed that the sheep belonging to the White Karaman-Kangal race were 18 times more likely to be infected with the virus. A decrease in apelin level was observed in the sheep with infection, and it was found that the risk of infection was 0.37 times higher in rams than in lactating sheep (p < 0.05).Öğe The Relationship of Mitochondrial-derived Peptide (MOTS-c) and Brain Mitochondrial Carrier Protein 1 (BMCP1) Response in Sheep with Some Physiological Parameters(Agricultural Research Communication Centre, 2024) Bayraktar, B.; Demir, N.; Aksakal, V.Background: Mitochondria are organelles called power plants of the cell, which are found in eukaryotic cells and are responsible for the production of energy needed by the cells through aerobic respiration. Mitochondrial dysfunction causes endocrinological, cardiovascular, metabolic and neurodegenerative diseases. The aim of this study was to examine the effects of body condition score (BCS), lactation, pregnancy, age and gender on Mitochondrial-Derived Peptide (MOTS-c) and Brain Mitochondrial Transporter Protein 1 (BMCP1) levels in Akkaraman sheep. Methods: Sheep are classified into 3 categories according to BCS (BCS<2, BCS=3-3.5, BCS >= 4). In creating groups in terms of BCS, it was determined by the palpation method applied to the waist area. The sheep included in the study were divided into 4 groups: early lactation, early pregnancy, late pregnancy (dry period) and age (female and male sheep).1(st) group, ewes in the first period of pregnancy (on the 100(th) day of the first pregnancy) (n = 30), 2(nd) group, ewes in the early lactation period (n = 30), 3(rd) group, ewes in the dry period (the last two months of pregnancy) (n = 30) and in the 4(th) group, <2 (young) (n=30), 2-8 (adult) (n=30), 8> (old) (n=30), male and female sheep (n=30) of different ages. =180) total of 270 animals. Blood samples were taken from the jugular vein of the sheep before the morning feeding. MOTSc and BMCP1 levels were determined in blood serum samples by ELISA method. Result: In the study, serum MOTS-c and BMCP1 levels in sheep during lactation and pregnancy were determined to be lowest in the VKS<2 group and highest in the VKS >= 4 groups. Likewise, in age and gender groups, the highest level was detected in young lambs and yearlings in the VKS<2 group, while the highest level was detected in old sheep and rams in the VKS >= 4 group. As a result, it was determined that different age, gender, pregnancy and lactation periods affected serum MOTS-c and BMCP1 levels depending on the change in BCS (P<0.05). It was concluded that MOTS-c and BMCP1 may be useful parameters in the evaluation of mitochondrial function, energy metabolism and metabolic profile.Öğe The Effect of Cannabidiol on Myokine, Cerebral and Cardiac Response in Rats with Sepsis Induced by Cecal Ligation and Punture Method(Agricultural Research Communication Centre, 2025) Erkilic, T. Orkun; Bayraktar, B.Background: the aim of this study was to investigate the effects of Cannabidiol on myokine (Irisin), cerebral (BDNF) and cardiac (cTnI) responses in sepsis-induced rats by Cecal Ligation Perforation (CLP) method. Methods: In this study, 40 adult male Wistar albino rats, aged between 8-10 weeks, were used. 5 groups were created, with 8 rats in each group: Control (C), Sham (S), CLP, CLP+CBD 2.5 mg/kg, CLP+CBD 5 mg/kg group. Rats in groups C and Sham were sacrificed at the end of the 10th hour and intracardiac blood was taken immediately afterwards. In groups CLP, CLP+2.5 mg/kg, CLP+5 mg/kg, intra-abdominal sepsis was induced and at the end of the 10th( )hour after sepsis occurred with CLP application, rats were sacrificed and intracardiac blood was taken immediately afterwards. Irisin, BDNF and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, mean serum irisin, BDNF and levels were determined to be at the lowest level in the CLP group, while cTnI levels were at the highest level (p<0.01). In CLP groups, serum irisin and BDNF levels increased due to CBD addition and the most significant decrease in cTnI levels occurred in 5 mg/kg CBD groups. As a result, it was concluded that CLP may be safe and beneficial when administered at a dose of 5 mg/kg in sepsis-induced rats.
