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Öğe Characteristic Properties of Spurge (Euphorbia macroclada Boiss.) Honey in Diyarbakır Region(Oktay YILDIZ, 2020) Kara, Yakup; Birinci, Ceren; Birinci, Esra; Can, ZehraSütleğen otu veya bitkisi (Euphorbia macroclada Bois.) ülkemizde yaygın olarak yetişen otsu bir bitki tür olup, her sütleğen otu bal nektar üretmez. Halk arasında sütlüce otu olarak da bilinen bu zehirli bitki, zehirli olmayan nektarlara sahiptir. Ülkemizde en yoğun olarak Güney Doğu Anadolu bölgesinde özellikle Diyarbakır ve Adıyaman bölgelerinde Ağustos ve Eylül aylarında üretilen sütleğen balı (haşul balı) apiterapik bal olarak çok değişik amaçlar için kullanılmaktadır. Mercimek ve nohut hasatından boş kalan tarlalarda yetişen sütleğen çiçeklerinden üretilmektedir. Sütleğen nektarına göre amber renginden oldukça koyu renge kadar değişen renk ve tatlardaki bu bal, oldukça vizkoz, kolay kristalize olmayan, hafif eksimsi bir tada ve aromaya sahiptir. Yapılan bu çalışmada ile ilk kez sütleğen balının bazı fiziko-kimyasal ve antioksidan özellikleri araştırıldı. Çiçek ballarınna göre daha yüksek Fruktoz/Glukoz oranı (1.4-1.7) ve yüksek fenolik madde miktarı (56-82 mg gallik asit (GAE/100 g) ve yüksek antioksidan kapasiteye ile apiterapötik değeri yüksek ballardan biridir. Ancak, yapılacak daha ileri çalışmalar bu balın gerçek biyolojik aktif değerini ortaya çıkaracaktır.Öğe Determination of phenolic content and bioactive characterization of Anatolian propolis(Springer, 2024) Can, Zehra; Birinci, Ceren; Kara, Yakup; Esertas, Ulku Zeynep Ureyen; Kolayli, SevgiIn this study, propolis referred to as of Turkiye Anatolian propolis was utilized. This work was aim to prepare a 70% ethanolic extract of propolis and subsequently determine certain biochemical parameters, total phenolic content (TPC), total flavonoid content (TFC), phenolic and flavonoid composition, inhibitory effects on certain enzymes [acetylcholinesterase (AChE), urease, and alpha-amylase], along with assessments of antiviral activity against Vero cells, lung cancer cells (A549), and breast cancer cells (MDA-MB-231). The richness of phenolic content in Anatolian propolis clearly indicates a high inhibitory effect on these enzymes. Additionally, it was observed to exert significant effects on cancer cells and demonstrated effective antiviral activity. It can be contemplated that the Anatolian propolis might serve as a potential source for novel drugs, and the isolation of its compounds could offer opportunities for utilization in traditional medicine.Öğe Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin(2023) Can, Zehra; Kara, Yakup; Güler, Halil İbrahim; Birinci, Ceren; Kolaylı, SevgiThis study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.Öğe Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin(2023) Can, Zehra; Kara, Yakup; Güler, Halil Ibrahim; Birinci, Ceren; Kolaylı, SevgiThis study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.Öğe Optimization of Phenolic Compound Extraction from Bee Products via Solvent Systems and PCA Integration(Springer, 2025) Birinci, Ceren; Kara, Yakup; Gidik, Betuel; Kolayli, Sevgi; Can, ZehraTo achieve a highly selective and sensitive analysis of phenolic compounds in bee products (honey, bee bread, and propolis), a simultaneous quantification of 25 phenolic compounds was performed using high-performance liquid chromatography coupled with a diode array detector. In the study, various solvents were utilized to enhance the phenolic profile of bee products, including pH 2 and 7 ultra-pure water, diethyl ether, and ethyl acetate. These included non-liquid-liquid extraction, pH 2 with 10 mL of pure water and 20 mL of diethyl ether; pH 2 with 10 mL of pure water and 20 mL of ethyl acetate; pH 2 with 10 mL of pure water, 10 mL of diethyl ether, and 10 mL of ethyl acetate; and pH 7 with 10 mL of pure water, 10 mL of diethyl ether, and 10 mL of ethyl acetate. Additionally, the integration of phenolic compounds identified through the enrichment method was pursued using principal component analysis (PCA). The extraction yields and recovery rates of phenolic compounds can be significantly improved by combining and integrating different extraction techniques. Our results demonstrated that using different solvent combinations significantly improved both the yield and diversity of phenolic compounds extracted from the complex matrices of bee products.
