Yazar "Can, Özgür Devrim" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    BENEFICIAL EFFECTS OF REBOXETINE ON IMPAIRED BEHAVIORAL PARAMETERS OF DIABETIC RATS
    (University of Ankara, 2022) Turan Yücel, Nazli; Kandemir, Ümmühan; Üçel, Umut Irfan; Can, Özgür Devrim; Demir Özkay, Ümide
    Objective: The incidence of emotional and cognitive disorders are higher in diabetic patients with respect to the general population. In this study, it was aimed to investigate the efficacy of reboxetine, a clinically prescribed drug for its antidepressant effect, on behavioral and cognitive alterations caused by diabetes in rats. Material and Method: An experimental diabetes model in rats was induced with a single 50 mg/kg injection of streptozotocin (i.v.). Reboxetine treatment was started 4 weeks after induction of diabetes in order to observe diabetic complications. Depression and anxiety levels of experimental animals were investigated by modified forced swimming and elevated plus-maze tests, respectively; cognitive performances were evaluated by Morris water-maze and passive avoidance experiments. The motor activities of the animals were also examined with the activity cage and Rota-rod tests. Result and Discussion: Obtained results indicated that the depression and anxiety levels of diabetic rats were increased and their cognitive performances were weakened. Reboxetine treatment (8 and 16 mg/kg) for two weeks reduced the elevated depression and anxiety levels in diabetic rats, while significantly improving their weakened cognitive performance. The findings indicated that reboxetine might possess a therapeutic potential for the cure of behavioral and cognitive impairements concomitant with diabetes. © 2022 University of Ankara. All rights reserved.
  • Küçük Resim Yok
    Öğe
    OPIOIDERGIC SYSTEM-MEDIATED ANTINOCICEPTIVE ACTIVITY OF TOFISOPAM
    (University of Ankara, 2022) Turan Yücel, Nazlı; Üçel, Umut İrfan; Yazici, Cevşen; Demi?R Özkay, Ümide; Can, Özgür Devrim
    Objective: In this study, it was aimed to investigate antinociceptive activity potential of Tofisopam and to elucidate the possible involvement of opioid system in this effect. Material and Method: The antinociceptive efficacy potential of Tofisopam (25 and 50 mg/kg) was evaluated by hot-plate and acetic acid-induced writhing tests; while possible effects of this drug on the motor coordinations of mice were evaluated with the Rota-rod tests. Result and Discussion: Tofisopam at a dose of 50 mg/kg significantly prolonged the reaction times of mice in hot-plate tests and reduced the number of writhing behaviors in writhing tests. These findings indicated that Tofisopam has antinociceptive activity mediated by central and peripheral mechanisms. Tofisopam did not change the motor activities of mice at administrated doses. Pre-administration of naloxone to investigate the possible involvement of opioid receptors in the antinociceptive effect abolished the antinociceptive activity of Tofisopam. To elucidate the opioid receptor subtypes mediating the effect, mechanistic studies were carried out with naloxonazine (?-opioid receptor blocker), naltrindole (?-opioid receptor blocker), and norbinaltorphimine (?-opioid receptor blocker). All agents antagonized the antinociceptive effect of Tofisopam. Obtained findings revealed that Tofisopam at a dose of 50 mg/kg has antinociceptive activity mediated by ?-, ?- and ?-opioid receptors. © 2022 Authors. All rights reserved.