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    Could eumelanin molecule from Streptomyces parvus BSB49 strain be a potential anticancer agent for lung cancer?
    (2023) Kızıl, Hamit Emre; Bayram, Sinan; Ozturk, Serdar; Karakas, Umit
    Melanins, which are divided into five different subgroups as eumelanin, pheomelanin, allomelanin, neuromelanin and pyomelanin, are a heterogeneous and amor- phous biopolymer family. Although melanin is produced in many different ways today, it is more practical, and more economical to produce melanin using bacterial strains. The eumelanin pigment, which is the subject of this study, was obtained using Streptomyces parvus BSB49 strain, and its antiproliferative effect at various concentrations against small cell (DMS-114) and non-small cell (H-460) lung cancer was determined. According to our results, the synthesized eumelanin molecule was statistically cytotoxic on non-small cell lung cancer cell line (H-460) at concentrations of 3.125 and 1.56 ?g/mL after 24 hours of treatment (IC50=8 ?g/mL) and only at a concentration of 3.125 ?g/mL after 48 hours of treatment (IC50=8.4 ?g/mL). In the small cell lung cancer cell line (DMS-114), no statistically cytotoxic concentration was detected (p<0.05).
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    Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes
    (Taylor & Francis Ltd, 2023) Uzun, Cosar; Erdal, Nurten; Ay, Ozlem Izci; Karakas, Umit; Yildirim, Didem Derici; Durukan, Huseyin; Akdag, Mahmut Berat
    The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.