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Öğe Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine(Gazi Univ, 2018) Hasanoglu Ozkan, Elvan; Kizil, Hamit Emre; Sakiyan, Iffet; Nartop, Dilek; Sari, Nursen; Agar, GulerayThe purpose of the research was to evaluate the genotoxic and anti-genotoxic properties of Schiff bases and their Mn (III) complexes containing L-aspartic acid, and L-phenylalanine. The anti-genotoxic properties of four compounds in human lymphocytes cells were investigated by sister chromatid exchanges (SCEs) test system against aflatoxin Bi (AFBi). The results showed that compounds have strong anti-genotoxic properties.Öğe Antiproliferative and apoptotic properties of vulpinic acid on A549, AGS and HeLa cells(Elsevier Science Bv, 2017) Kizil, Hamit Emre; Agar, Guleray[Abstract Not Available]Öğe Antiproliferative effects of Evernic acid on A549 and healthy human cells: An in vitro study(Elsevier Science Bv, 2015) Kizil, Hamit Emre; Agar, Guleray; Anar, Mustafa[Abstract Not Available]Öğe Cytotoxic and antiproliferative effects of evernic acid on HeLa cell lines: A candidate anticancer drug(Elsevier Science Bv, 2014) Kizil, Hamit Emre; Agar, Guleray; Anar, Mustafa[Abstract Not Available]Öğe DETERMINATION OF ANTIGENOTOXIC EFFECTS OF FOUR LICHEN SPECIES BY USING HUMAN LYMPHOCYTES(Parlar Scientific Publications (P S P), 2015) Anar, Mustafa; Aslan, Ali; Ceker, Selcuk; Kizil, Hamit Emre; Alpsoy, Lokman; Agar, GulerayIn this study, the geno-toxic and antigeno-toxic properties of the total extracts of four lichen species were investigated by using human lymphocytes. We obtained total extracts from R. farinacea, X parietina, U articulata and U. filipendula lichen species. The results of our studies showed that 5 mu M concentrations of AFB(1) changed the frequencies of micronucleus (MN) and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx) activities. When 5, 10 and 20 mu g/ml concentrations of total extract were added to AFB(1), the frequencies of MN and MDA levels were decreased, and SOD, GSH and GPx levels were increased. Consequently, our findings show that four lichen total extracts have strong antigenotoxic properties against aflatoxin B-1.Öğe The determination of antioxidative effect and anticancer potential of vulpinic acid(Elsevier Science Bv, 2014) Anar, Mustafa; Kizil, Hamit Emre; Agar, Guleray[Abstract Not Available]Öğe Determination of cytotoxic and proliferative effects of 2-amino-5-nitrobenzonitrile on AGS cancer cell line(Elsevier Science Bv, 2015) Anar, Mustafa; Kizil, Hamit Emre; Agar, Guleray[Abstract Not Available]Öğe Determination of the Antigenotoxic effects of Evernic acid against genotoxic effects of CCL4 on HUVEC lines(Elsevier Science Bv, 2017) Agar, Guleray; Kizil, Hamit Emre; Ceker, Selcuk; Capik, Ozel; Sengul, Bulent[Abstract Not Available]Öğe Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways(Springer, 2023) Kizil, Hamit Emre; Caglayan, Cuneyt; Darendelioglu, Ekrem; Ayna, Adnan; Gur, Cihan; Kandemir, Fatih Mehmet; Kucukler, SefaBackgroundOrgan toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling.Methods and resultsRats were subjected to oral treatment of morin (50 and 100 mg/kg body weight) for 10 days. Hepatotoxicity was induced by single intraperitoneal injection of MTX (20 mg/kg body weight) on the 5th day. MTX related hepatic injury was associated with increased MDA while decreased GSH levels, the activities of endogen antioxidants (glutathione peroxidase, superoxide dismutase and catalase) and mRNA levels of HO-1 and Nrf2 in the hepatic tissue. MTX treatment also resulted in apoptosis in the liver tissue via increasing mRNA transcript levels of Bax, caspase-3, Apaf-1 and downregulation of Bcl-2. Conversely, treatment with morin at different doses (50 and 100 mg/kg) considerably mitigated MTX-induced oxidative stress and apoptosis in the liver tissue. Morin also mitigated MTX-induced increases of ALT, ALP and AST levels, downregulated mRNA expressions of matrix metalloproteinases (MMP-2 and MMP-9), MAPK14 and MAPK15, JNK, Akt2 and FOXO1 genes.ConclusionAccording to the findings of this study, morin may be a potential way to shield the liver tissue from the oxidative damage and apoptosis.
