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    Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine
    (Gazi Univ, 2018) Hasanoglu Ozkan, Elvan; Kizil, Hamit Emre; Sakiyan, Iffet; Nartop, Dilek; Sari, Nursen; Agar, Guleray
    The purpose of the research was to evaluate the genotoxic and anti-genotoxic properties of Schiff bases and their Mn (III) complexes containing L-aspartic acid, and L-phenylalanine. The anti-genotoxic properties of four compounds in human lymphocytes cells were investigated by sister chromatid exchanges (SCEs) test system against aflatoxin Bi (AFBi). The results showed that compounds have strong anti-genotoxic properties.
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    Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases
    (2020) Nartop, Dilek; Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Ağar, Güleray; Sarı, Nurşen
    In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL1, NiL2, NiL3, NiL4) were prepared by a twostage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-inducedantimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN)methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce themutagenicity caused by sodium azide (NaN3) which is used as a positive control.
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    Synthesis of novel polymers containing Schiff base as potential antimutagenic and antimicrobial agents
    (Sami Publishing Company, 2020) Nartop, Dilek; Tokmak, Erkan; Özkan, Elvan Hasanoğlu; Kızıl, Hamit Emre; Öğütcü, Hatice; Ağar, Güleray; Allı, Sema
    In this research study, two novel polymers including Schiff base were prepared by condensation reaction of polystyrene-A-NH2 with 5-nitro-2-thiophenecarboxaldehyde/or 5-(2-nitrophenyl)-2-furancarboxaldehyde. The synthesized polymers were evaluated using the elemental analysis, infrared spectroscopy (IR), gel permeation chromatography (GPC), thermal gravimetric analysis (TG/DTA). In addition, the antimicrobial and antimutagenic study of the polymers were reported. The antibacterial and antifungal activity were investigated using the diffusion method against pathogenic bacterial strains. PA-TC and PA-FC polymers exhibited the highest antimicrobial activity against the S. typhi H. and P. vulgaris, respectively. PA-FC polymer revealed the highest antifungal activity against C. albicans. The antimutagenic effects were evaluated using the sister chromatid exchange (SCE) and micronucleus (MN) methods against the sodium azide (NaN3) in human lymphocyte cells. The results demonstrated that the PA-FC polymer have strong antimutagenic properties, especially in the concentration of 20 µg/mL. © 2020 by SPC (Sami Publishing Company)