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    Effects of electromagnetic radiation on neurogenesis and gene expression in amniocytes
    (Taylor & Francis Ltd, 2023) Uzun, Cosar; Erdal, Nurten; Ay, Ozlem Izci; Karakas, Umit; Yildirim, Didem Derici; Durukan, Huseyin; Akdag, Mahmut Berat
    The aim of the study was to investigate the genetic effects of commonly used radiofrequency on the amniocytes of pregnant women by examining the changes in the expression of genes related to signal transduction and neurogenesis induced by electromagnetic fields of radiofrequencies of 1800 and 2100 MHz by real-time PCR. Upon exposure of the amniocytes to electromagnetic radiation of 2100 MHz at high field strength, the expression levels of genes with important functions in the Wnt signaling pathways as well as neurogenesis-related genes were increased. The findings suggest that radiofrequency at high field strengths can have genotoxic effects during pregnancy.
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    Short-Term Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Wnt Signaling in Amniotic Fluid Cells
    (Necmettin Erbakan Univ, Fac Medicine-Neu Press, 2025) Uzun, Cosar; Karakas, Umit; Ay, Mustafa Ertan; Ay, Ozlem Izci; Yildiri, Didem Derici; Erdal, Nurten; Erdal, Mehmet Emin
    Background: Extremely low-frequency electromagnetic fields (ELF-EMF) at 50 Hz are prevalent in household electrical systems. Although various studies have examined the effects of ELF-EMF on cell proliferation and gene expression, its impact on amniotic fluid cells (AFCs) remains unclear. Objectives: This study aimed to assess the potential effects of ELF-EMFs on gene expression related to neurogenesis and the Wnt signaling pathway in AFCs. Methods: AFCs were isolated from amniotic fluid obtained via amniocentesis and divided into five groups: control, sham, and three groups exposed to different ELF-EMF intensities (1 mT, 2 mT, 3 mT for 30 minutes/day for 7 days). Expression levels of genes involved in neurogenesis (HES1, Neurog1, Neurog2, Neurod1) and Wnt signaling (SFRP2, SFRP4, SFRP5, APC1) were analyzed using real-time PCR. Results: ELF-EMF exposure did not result in significant changes in gene expression among the experimental groups compared to controls. Conclusion: Short-term exposure (Acute exposure) to ELF-EMF at moderate intensities does not significantly impact gene expression related to neurogenesis or Wnt signaling in AFCs. Future studies should explore prolonged exposure (chronic exposure) and a broader range of intensities to evaluate developmental impacts more comprehensively.