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    Synthesis and Characterization of Fe(II) and Cu(II) Complexes of N-(benzothiazol-2-yl)benzamide Derivatives
    (Bayburt University, 2025) İlkimen, Halil; Yenikaya, Cengiz; Gülbandılar, Aysel
    There is a need for chemicals that are resistant to these diseases because the sensitivity of microorganisms that cause diseases in living beings to the drugs used against them is gradually decreasing. Therefore, new Fe(II) {[Fe(abt)2(SO4)].H2O (1) and [Fe(smabt)2(SO4)].H2O (2)} and Cu(II) {[Cu(abt)2(Ac)2].4H2O (3) and [Cu(abt)2(Ac)2].4H2O (4)} complexes of N-(benzothiazol-2-yl)benzamide (abt) and 4-chloro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (smabt) were synthesized. The structures of 1-4 were suggested by elemental analysis, AAS, IR, molar conductivity and magnetic susceptibility methods. As a result of spectroscopic evaluation, compounds 1-4 were suggested to be nonionic and have tetrahedral geometry. Additionally, the antimicrobial activities of all substances against C. albicans (yeast), E. faecalis, E. coli, L. monocytogenes, S. aureus, P. aeruginosa and B. subtilis (bacteria) were investigated and compared with Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin and Cefepime. All substances were observed to have antimicrobial properties against bacteria or yeast. When the antimicrobial activities of the starting materials (abt, smabt) and complexes (1-4) were compared, the same activity was observed against S. aureus (except 4), E. coli (except 1), B. subtilis, E. faecalis, L. monocytogenes bacteria, and C. albicans yeast. 4 showed less activity in S. aureus bacteria, 1 showed more activity in E. coli bacteria. In P. aeruginosa bacteria, the following effects were observed: 1 > 3, smabt > abt, 2, 4.
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    Synthesis and Characterization of Proton Transfer Salts of 2-Aminobenzothiazole Derivatives
    (Bayburt University, 2022) İlkimen, Halil; Yenikaya, Cengiz
    In this study, (E)-4-oxo-4-(3-sulfamoylphenyl)amino)but-2-enoic acid (Habsmal) was first obtained from the reaction of maleic anhydride (mal) with 3-aminobenzenesulfonamide (abs). Then, salts of 2-aminobenzothiazole (abt) (1) and 2-amino-6-ethoxybenzothiazole (EtOabt) (2) were synthesized by Habsmal. In addition, proton transfer salts were obtained from the reactions of 5-sulfosalicylic acid (H3ssa) with 2-amino-6-hydroxybenzothiazole (HOabt) (3) and 2-amino-6-nitrobenzothiazole (NO2abt) (4). The structures of proton transfer salts obtained in amorphous state have been proposed by elemental analysis, NMR (1H and 13C), FT-IR, charge balance and previous studies. According to the results of this analysis, the acid and base association ratios were found to be 1:1
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    Synthesis, Characterization and Investigation of Antimicrobial Activities of Metal Complexes of (E)-4-oxo-4-(3-sulfamoylphenyl)amino)but-2-enoic Acid
    (Bayburt University, 2023) İlkimen, Halil; Yenikaya, Cengiz; Gülbandılar, Aysel
    In this study, Fe(II) (2) {[Fe(1)2]}, Co(II) (3) {[Co(1)2].3H2O}, Ni(II) (4) {[Ni(1)2].3H2O}, Cu(II) (5) {[Cu(1)2]} and Zn(II) (6) {[Zn(1)2].3H2O} complexes of (E)-4-oxo-4-(4-sulfamoylanilino)but-2-enoic acid (1) were synthesized and their structures were suggested by AAS, IR, UV-vis, magnetic moment and molar conductivity measurements. In addition, compounds 1-6 of antimicrobial activities against Bacillus subtilis, Listeria monocytogenes (ATCC 7644), Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (NRRL-B 767) (Gram positive), Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (ATCC 25922) (Gram negative) (bacteria) and Candida Albicans (ATCC 14053) (yeast) were tested using the microdilution method. Antifungal activity results were compared with the control compound Fluconazole, while antibacterial results were compared with Levofloxacin, Cefepime and Vancomycin. As a result of the activity studies, it was observed that the newly synthesized compounds had antimicrobial activity against bacteria and yeasts. In the activity results of the compounds, 1-6 in B. subtilis bacteria, 2-6 in E. faecalis bacteria, 1-6 in S. aureus bacteria, 4 and 5 in E. coli bacteria, 1, 3, 5 and 6 in L. monocytogens bacteria, 1, 3 and 5 in P. aeruginoa bacteria and 2-4 in C. albicans yeast were observed.