4,4'-Bipiridin ve Anilin-2,5-Disülfonik Asidin Karışık Ligandlı Metal Komplekslerinin Sentezi, Karakterizasyonu ve Antimikrobiyal Aktivitesi
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayburt Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada 4,4'-bipiridin (BP) ve anilin-2,5-disülfonik asit (H2ADSA) ile karışık ligandlı Co(II) {[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) {[Ni(ADSA)(BP)]n, 2} ve Zn(II)) {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} kompleksleri hazırladı. 1-3 Element analizi, AAS, TGA, IR, UV-Vis, molar iletkenlik ve manyetik duyarlılık teknikleri ile karakterize edildi. Ayrıca mikrodilüsyon yöntemi ile başlangıç maddeleri ve sentezlenen metal komplekslerinin aşağıdaki bakteriler ve mayaya karşı antibakteriyel ve antifungal aktivitelerini araştırmak için kullanıldı: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis ve Candida albicans. Antibakteriyel ve antifungal aktivite sonuçları antibiyotiklerle (Vankomisin, Levofloksasin, Sefepim, Kloramfenikol, Flukonazol ve Ketokonazol) karşılaştırıldı. Yapılan çalışmalar incelendiğinde, yeni oluşturulan bileşiklerin hem bakteri hem de maya enfeksiyonlarıyla mücadelede aktivite gösterdiği gözlenmiştir.
In this study, we prepared mixed-ligand Co(II) complex{[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) complex {[Ni(ADSA)(BP)]n, 2}, and Zn(II) complex {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} of 4,4'-bipyridine (BP) with aniline-2,5-disulfonic acid (H2ADSA). The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics (Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole). Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.
In this study, we prepared mixed-ligand Co(II) complex{[Co(ADSA)(BP)]n.2H2O, 1}, Ni(II) complex {[Ni(ADSA)(BP)]n, 2}, and Zn(II) complex {[Zn(ADSA)(BP)(H2O)2]n.3H2O, 3} of 4,4'-bipyridine (BP) with aniline-2,5-disulfonic acid (H2ADSA). The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics (Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole). Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.
Açıklama
Anahtar Kelimeler
Chemical Engineering (Other), Kimya Mühendisliği (Diğer)
Kaynak
Bayburt Üniversitesi Fen Bilimleri Dergisi
Bayburt Üniversitesi Fen Bilimleri Dergisi
Bayburt Üniversitesi Fen Bilimleri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
2
