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Öğe Antioxidant effect of Rosa pimpinellifolia L. fruit extract on cholestatic liver injury: an experimental study(Assoc Medica Brasileira, 2024) Demircioglu, Mahmut Kaan; Demircioglu, Zeynep Gul; Cakir, Ozlem; Yanar, Karolin; Ozguven, Muveddet Banu Yilmaz; Atukeren, Pinar; Gulcicek, Osman BilginBACKGROUND: Antioxidants have been considered a rational curative strategy to prevent and cure liver diseases involving oxidative stress. An acute obstructive jaundice rat model was established to investigate the in vivo hepatoprotective efficacy of Rosa pimpinellifolia L.METHODS: The experimental jaundice model was performed by binding the main bile duct in 25 male Sprague-Dawley rats. All rats were randomly divided into five groups: first group: laparotomy-sham-only, second group: biliary tract binding (control), and third, fourth, and fifth groups: treatment groups with 250, 500, and 750 mg/kg fruit extracts daily, respectively.RESULTS: Considering dosage, although there was no significant therapeutic effect in the 250 mg/kg of Rosa pimpinellifolia L. group, the best results were found in the 500 mg/kg dose group, while results in the 750 mg/kg dose group showed consistent correlation with proinflammatory response. With regard to biochemical parameters, lipid hydroperoxide level in the rat serum and liver tissue was significantly decreased in all treatment groups. Amadori products, which are one of the early markers of glycol-oxidative stress, showed statistical significance in the treatment.CONCLUSION: It was revealed that the antioxidant effect of Rosa pimpinellifolia L. was more prominent in the early stages of hepatic injury secondary to oxidative stress.Öğe Bioactive Characteristics of Wild Berberis vulgaris and Berberis crataegina Fruits(Hindawi Ltd, 2020) Eroglu, Arzu Yasar; Cakir, Ozlem; Sagdic, Mustafa; Dertli, EnesThere is an increasing trend to find novel sources of products with high antioxidant capacity and wild fruits are very good examples for these sources. In this study, fruits ofBerberis vulgarisandBerberis crataegina, naturally grown in Bayburt province of Turkey, were tested for their physicochemical features, antioxidant capacities, phenolic compound profiles, and antimicrobial activities. The physicochemical analysis of the fruits revealed that the dry matter content, ash content, pH, anda(w)values were between 28.47% and 41.61%, 0.65% and 2.13%, 2.44 and 3.25, and 0.996 and 0.97, respectively. The total phenolic content of the fruits was determined by the Folin-Ciocalteu methodology, and for the determination of the antioxidant capacity of the fruits, DPPH, ABTS, and beta-carotene bleaching methods were performed and a high level of antioxidant activity was observed. HPLC analysis was applied to identify the phenolic content of the fruits, and gallic acid and chlorogenic acid were found to be the dominant phenolic compounds inBerberisfruits. The water extracts of theBerberisfruits were tested against important foodborne pathogenic bacteria as potential antimicrobials. The extracts inhibited the growth ofBacillus cereus,Salmonella typhimurium,Yersinia enterocolitica, andStaphylococcus aureusat significant rates. This study revealed the potential antioxidant and antimicrobial characteristics of wild-typeB. vulgarisandB. crataeginathat can be used for different future applications.Öğe A Comparative Study on the Bioactivity and Mineral Content of Different Grapevine (Vitis vinifera L.) Leaves Cultivated in Türkiye(Springer, 2024) Yildiz, Hilal; Cakir, Ozlem; Cakiroglu, Kubra; Karatas, NevaThe mineral composition, total phenolic content, radical scavenging, and antibacterial activity of 17 Vitis vinifera L. leaves obtained from vineyards in northeast Turkiye were investigated in this study. The antibacterial activities of grapevine leaf extracts were investigated by the disk diffusion method against five bacterial strains, and all leaf extracts showed inhibitory activity on both Bacillus cereus and Staphylococcus aureus. The radical scavenging activity of grapevine leaf extracts was evaluated using the DPPH (2,2-diphenyl-1-picryl hydrazyl) and ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) assays. The 'Gines' cultivar had the highest level of radical scavenging activity, while the 'Ciklap' cultivar had the lowest. The total phenolic content of leaf extracts was in the range of 172.66-483.33 mu g GAE/mg DW. Grapevine leaf extracts were examined in terms of 15 different elements. The most abundant element in varieties of grapevine leaves was potassium, and its concentration varied between 5208.83 and 13,586.49 mg/kg. The results indicated that V. vinifera L. leaves had strong antioxidant and antibacterial activity, and the varieties of grapevine had a significant impact on these parameters (p < 0.001). Mineral and trace element contents were also significantly affected by cultivars (p < 0.05).Öğe Comparison of two wild-grown Berberis varieties based on biochemical characterization(Wiley, 2020) Cakir, Ozlem; Karabulut, AbdulkadirIn this study, some physicochemical properties, antioxidant activity, total phenolic content, mineral content, and phenolic profiles ofBerberis vulgarisandBerberis crataeginawild-grown in Bayburt are analyzed and compared. The level of total phenolic content inB. crataeginaDC. (73.48 mu g GAE/mg KM) was found higher thanB. vulgaris(71.54 mu g GAE/mg KM). According to three methods (beta-carotene, 2,2-diphenyl-1-picrylhydrazyl, and cupric reducing antioxidant capacity) the antioxidant activity of theB. crataeginais also higher. The change in color (L*,b*) is found statistically important (p < .05). There are no meaningful differences between the dry matter, C vitamin, pH value, and water activity (p > .05). It was observed that the fruit type has a great effect on brix and ash content (p < .05) and glucose, total sugar, and malic acid content. Chlorogenic acid is the dominant phenolic component for both types. It is followed by syringic, sinapic, and gallic acid inB. vulgarisand sinapic, syringic, and gallic acid inB. crataegina. Practical applications Wild fruits have been consumed for centuries in nutrition or pharmacology applications. They are known as rich resources of antioxidant and phenolic compounds. For that reason, wild fruits play an important role in the prevention and treatment of some diseases especially cardiovascular diseases and cancer. In this study, wild-grownB. vulgarisandB. crataeginawere analyzed in detail according to their bioactive properties and an assessment was made in terms of industrial and medical usability. This study reports mineral content, antioxidant activity, total phenolic content, and the phenolic acid profile (sinapic, syringic, gallic, chlorogenic, caffeic, vanillic,trans-ferulic,p-coumaric, and 4-hydroxybenzoic acids) of two Berberis varieties. According to results, these fruits may be used as natural flavoring and coloring material in food sector. Thanks to the active ingredients and minerals; these fruits may be used in pharmaceutical industry. They have a good potential for commercial exploitation and positive effects on health.Öğe Optimization of pectin extraction from crab apple peel and usage in a model meat emulsion system(Springer, 2024) Aldemir, Hazal; Kamiloglu, Aybike; Cakir, OzlemThe aim of this study was to optimize conditions of microwave-assisted pectin extraction from crab apple peels using the Box-Behnken experimental design. For this purpose, microwave-assisted pectin extraction was performed at different extraction time (3, 6, and 9 min), liquid/solid ratio (75, 100, and 125), and pH (1.5, 2.0, 2.5). The optimum conditions were selected as extraction time (7.77 min), liquid/solid ratio (77.53 mL/g), and pH/1.79). The response, obtained under optimum conditions was determined as 0.1128 +/- 0.0137 g pectin/g crab apple peel. In addition, it was determined that the obtained pectin sample had an esterification degree of 79.14% and oil and water binding capacities of 8.5 +/- 0.7 g oil/g pectin and 8.1 +/- 1.5 g water/g pectin, respectively. It was determined that pectin emulsions showed higher stability at 1% pectin level. The possibilities of using pectin obtained under optimized conditions as a fat replacer in a model sausage system were investigated. Pectin was evaluated in the model sausage system at two different concentrations. With the increasing pectin concentration, the cooking loss value increased from 14 to 18%, while leakage decreased from 0.31% to 0.18%, showing a negative effect on cooking loss and a positive impact on the amount of leakage into the packaging. Pectin obtained from crab apple peel has the potential to be used for reducing fat content in sausage environment.Öğe ORGANIC ACIDS, SUGARS AND MINERAL CONTENT OF CHERRY LAUREL (LAUROCERASUS OFFICINALIS ROEM.) ACCESSIONS IN TURKEY(Publ House Bulgarian Acad Sci, 2016) Esringu, Aslihan; Aksic, Milica Fotiric; Ercisli, Sezai; Okatan, Volkan; Gozlekci, Sadiye; Cakir, OzlemIn this study we report on the content of organic acids, sugars and minerals in the pulps of the twelve cherry laurel accessions most commonly consumed in eastern Black Sea Region. Malic acid was the dominant organic acid ranged from 43.27 (CL6) to 54.23 (CL3) mg/100 g fresh weight basis. The dominant sugars were glucose and fructose in the pulps that ranged from 4.83 (CL1) to 5.74 (CL5) mg/100 g and 4.66 (CL3) to 5.53 (CL7) mg/100 g, respectively. The pulp of cherry laurel was shown to be rich in potassium (187-241 mg), phosphorus (26-45 mg), calcium (15-22 mg), magnesium (15-24 mg) and sodium (3.9-6.1 mg) in 100 g fruit pulp. The data may be useful in selecting wild edible fruit species appropriate for incorporation into diets.Öğe Phytochemical profile, enzyme inhibition, antioxidant, and antibacterial activity of Rosa pimpinellifolia L.: A comprehensive study to investigate the bioactivity of different parts (whole fruit, pulp, and seed part) of the fruit(Elsevier Sci Ltd, 2024) Findik, Bahar Tuba; Yildiz, Hilal; Akdeniz, Mehmet; Yener, Ismail; Yilmaz, Mustafa Abdullah; Cakir, Ozlem; Ertas, AbdulselamThe pharmaceutical and nutraceutical potentials of whole fruit, pulp and seeds of Rosa pimpinellifolia L. were evaluated. Forty-two phenolic compounds and two triterpenoids were identified in extracts by LC-MS/MS and GC -MS, respectively. The most prominent compounds were ellagic acid, catechin, epicatechin, tannic acid, quercetin, oleanolic acid, and ursolic acid. The highest enzyme inhibitory activities of the extracts (94.83%) were obtained against angiotensin-converting enzyme and were almost equal to those of the commercial standard (lisinopril, 98.99%). Whole fruit and pulp extracts (IC 50 :2.47 and 1.52 mu g DW/mL) exhibited higher antioxidant capacity than the standards ( alpha-tocopherol, IC 50 :9.89 mu g DW/mL). The highest antibacterial activity was obtained against Bacillus cereus (MIC: 256 mu g/mL) for the whole fruit extract. Correlation analyses were conducted to find the correlation between individual phenolics and enzyme inhibitory activities. The results showed the remarkable future of not only the edible part but also the seeds of black rose hips in phytochemical and functional aspects.Öğe PHYTOCHEMICAL PROFILES OF WILD GROWN BLACKBERRY AND MULBERRY IN TURKEY(Univ Life Sciences Lublin, 2016) Akin, Meleksen; Eyduran, Sadiye Peral; Ercisli, Sezai; Yilmaz, Ilker; Cakir, OzlemBlackberry and mulberry are main berry crops grown in Black Sea region mostly in humid shade forest areas and its important for local people's diet and also important for the maintenance of their health and prevention of disease. Present study aimed to determine the content of vitamin C, organic acids (citric acid, tartaric acid, oxalic acid, malic acid, succinic acid, fumaric acid), sugars (glucose and fructose) and phenolic compounds (catechin, rutin, quercetin, chlorogenic acid, ferulic acid, o-coumaric acid, p-coumaric acid, caffeic acid, syringic acid, vanillic acid, and gallic acid), as well as antioxidant capacity (Trolox Equivalent Antioxidant Capacity, TEAC assay) in the wild grown blackberry and mulberry fruit. Among phenolic acids, chlorogenic acid was the predominant for all wild grown blackberries, white and black mulberries. The presence of oxalic acid was only detected in the wild blackberry genotype. As a result, the phytochemical recognition of the wild grown blackberry, black and white mulberries might contribute to forthcoming investigations for developing the efficiency of food industry.Öğe Seed-Propagated Summer Apples: Great Morphological and Biochemical Diversity(Mdpi, 2021) Karatas, Neva; Ercisli, Sezai; Bozhuyuk, Mehmet Ramazan; Cakir, Ozlem; Necas, Tomas; Ondrasek, IvoThe northeastern Anatolia region of Turkey is one of the richest plant biodiversity areas in Turkey. This study describes some important tree and fruit characteristics of 20 seed-propagated summer apple genotypes from northeastern Anatolia using morphological and biochemical markers. The genotypes were evaluated morphologically for tree growth habit, ripening date, fruit weight, fruit firmness, fruit shape, fruit color, fruit taste, juiciness and aroma. The biochemical characteristics measured were organic acids, SSC (soluble solid content), titratable acidity, vitamin C, total phenolic content and antioxidant capacity. We found significant differences for most of the morphological and biochemical characteristics. The genotypes exhibited quite diverse harvest dates ranging from 4 July to 16 August. Summer apple genotypes had fruit weight between 101.9 g and 133.5 g. The genotypes had diverse fruit shapes, including round, conic and oblate, and over fruit colours such as pink, red, yellow and green. Genotypes GUM7 and GUM13 stood out for fruit weight, SSC, total phenolic and antioxidant capacity. GUM7 and GUM13 present dissimilarity from the other genotypes. While the first showed a lower average fruit weight, SSC, total phenolic content and antioxidant capacity, the second revealed higher average of fruit weight, total phenolic content, antioxidant capacity and higher SSC. Due to their favorable characteristics, GUM13 can be used for further crosses with genotypes of other groups, which also present favorable characteristics.
