Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.

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dc.contributor.authorCan, Zehra
dc.contributor.authorDemir, Elif Ayazoglu
dc.contributor.authorAkar, Zeynep
dc.contributor.authorKara, Yakup
dc.contributor.authorGıdık, Betül
dc.date.accessioned2024-10-04T19:04:19Z
dc.date.available2024-10-04T19:04:19Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe study aims to investigate the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhibition and cytotoxic effects of two different Artemisia spp. (Artemisia dracunculus L. and Artemisia dracunculoides Pursh) cultivated in Türkiye organically, for the first time. The total phenolic and total flavonoid contents of the plants were determined spectrophotometrically while antioxidant activity DPPH•, CUPRAC, and FRAP was determined using the colorimetric method. And also, acetylcholinesterase in vitro enzyme inhibition activity and anti-cancer activity against human melanoma (VMM917, CRL-3232), lung carcinoma (A549, CCL-185), and normal human fibroblast (hGF, PCS-201-018) cells were studied. Total phenolic (225-324 ?g GAE/mL extract) and total flavonoid contents (0.066-0.085 ?g QE/mL extract), antioxidant activity Color Scavenging Concentration 50% (DPPH• (CSC50: 1.371-1.655 mg/mL), CUPRAC (0.246-0.344 ?M CTEAC) and FRAP (462.133-726.661 ?M CTEAC)). A. dracunculus and A. dracunculoides extracts inhibited 40.09 ± 0.65%, and 39.48 ± 3.68% of acetylcholinesterase activity. It was determined that demonstrated the selective effect of A. dracunculus and A. dracunculoides on the cytotoxicity of A549 and hGF cells. According to our results, both tarragon plant species, it may be said that it is not only consumed as food but also used for therapeutic purposes will be beneficial for health.en_US
dc.identifier.doi10.51435/turkjac.1246389
dc.identifier.endpage10en_US
dc.identifier.issn2687-6698
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid1188750en_US
dc.identifier.urihttps://doi.org/10.51435/turkjac.1246389
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188750
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4283
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Analytical Chemistry (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArtemisia dracunculusen_US
dc.subjectArtemisia dracunculoidesen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectlung carcinomaen_US
dc.subjecthuman melanomaen_US
dc.titleDetermination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.en_US
dc.typeArticleen_US

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