From Synaptic Dysfunction to Memory Recovery: Ampakine Compounds as Potential Therapeutic Agents for Alzheimer's Disease

Basit Öğe Kaydı
dc.contributor.authorÖzten, Ömer
dc.date.accessioned2026-02-28T12:40:56Z
dc.date.available2026-02-28T12:40:56Z
dc.date.issued2023
dc.departmentBayburt Üniversitesi
dc.description.abstractAlzheimer's disease, a profoundly impactful neurodegenerative condition, manifests as the progressive deterioration of memory and cognitive functions. Studies have shown that memory decline is associated with a decrease in the rapid transmission of excitatory signals between neurons. The limited research on the positive impact of AMPA receptor modulation has prompted the exploration of Ampakine compounds. Ampakines enhance long-term potentiation (LTP) by activating receptors, which exists in a crucial role in memory preservation. The ability of ampakine compounds to bind to AMPA receptors and increase the expression of neurotrophic factors, such as BDNF, is believed to mitigate LTP impairment. Recent studies have demonstrated that certain ampakine compounds can enhance consciousness and memory storage by promoting the production of various neurotrophins, particularly BDNF and NGF. Previous research has shown that neurotrophins contribute to synaptogenesis, the formation of new connections between neurons, primarily through dendritic spines. Increasing synaptogenesis via dendritic spines positively impacts signal transmission and retention by strengthening neuronal connections. This review highlights the potential of ampakine compounds such as pesampator and hydroflumetazide to enhance synaptic interactions, alleviate symptoms of Alzheimer's disease, and specifically address memory loss through their effects on neurotrophins.
dc.identifier.endpage191
dc.identifier.issn2980-194X
dc.identifier.issue3
dc.identifier.startpage167
dc.identifier.urihttps://hdl.handle.net/20.500.12403/7243
dc.identifier.volume1
dc.language.isoen
dc.publisherAtatürk Üniversitesi
dc.relation.ispartofRecent Trends in Pharmacology
dc.relation.ispartofRecent Trends in Pharmacology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260218
dc.subjectPharmaceutical Sciences
dc.subjectEczacılık Bilimleri
dc.titleFrom Synaptic Dysfunction to Memory Recovery: Ampakine Compounds as Potential Therapeutic Agents for Alzheimer's Disease
dc.typeReview Article

Dosyalar

Koleksiyon

Öksüz Yayınlar Koleksiyonu