Short-Term Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Wnt Signaling in Amniotic Fluid Cells

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dc.contributor.authorUzun, Cosar
dc.contributor.authorKarakas, Umit
dc.contributor.authorAy, Mustafa Ertan
dc.contributor.authorAy, Ozlem Izci
dc.contributor.authorYildiri, Didem Derici
dc.contributor.authorErdal, Nurten
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2026-02-28T12:18:22Z
dc.date.available2026-02-28T12:18:22Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: Extremely low-frequency electromagnetic fields (ELF-EMF) at 50 Hz are prevalent in household electrical systems. Although various studies have examined the effects of ELF-EMF on cell proliferation and gene expression, its impact on amniotic fluid cells (AFCs) remains unclear. Objectives: This study aimed to assess the potential effects of ELF-EMFs on gene expression related to neurogenesis and the Wnt signaling pathway in AFCs. Methods: AFCs were isolated from amniotic fluid obtained via amniocentesis and divided into five groups: control, sham, and three groups exposed to different ELF-EMF intensities (1 mT, 2 mT, 3 mT for 30 minutes/day for 7 days). Expression levels of genes involved in neurogenesis (HES1, Neurog1, Neurog2, Neurod1) and Wnt signaling (SFRP2, SFRP4, SFRP5, APC1) were analyzed using real-time PCR. Results: ELF-EMF exposure did not result in significant changes in gene expression among the experimental groups compared to controls. Conclusion: Short-term exposure (Acute exposure) to ELF-EMF at moderate intensities does not significantly impact gene expression related to neurogenesis or Wnt signaling in AFCs. Future studies should explore prolonged exposure (chronic exposure) and a broader range of intensities to evaluate developmental impacts more comprehensively.
dc.identifier.issn2146-4596
dc.identifier.issn2146-460X
dc.identifier.issue3
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6232
dc.identifier.volume14
dc.identifier.wosWOS:001651398600003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherNecmettin Erbakan Univ, Fac Medicine-Neu Press
dc.relation.ispartofJournal of Pediatric Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260218
dc.subjectAmniotic fluid cells
dc.subjectExtremely low-frequency
dc.subjectelectromagnetic fields
dc.subjectNeurogenesis
dc.subjectWnt signaling
dc.subject50 Hz
dc.titleShort-Term Effects of Extremely Low-Frequency Electromagnetic Fields on Neurogenesis and Wnt Signaling in Amniotic Fluid Cells
dc.typeArticle

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