Determination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.

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dc.contributor.authorCan, Zehra
dc.contributor.authorDemir, Elif Ayazoglu
dc.contributor.authorAkar, Zeynep
dc.contributor.authorKara, Yakup
dc.contributor.authorGıdık, Betül
dc.date.accessioned2026-02-28T11:58:24Z
dc.date.available2026-02-28T11:58:24Z
dc.date.issued2023
dc.departmentBayburt Üniversitesi
dc.description.abstractThe study aims to investigate the antioxidant activities, phenolic compounds, acetylcholinesterase enzyme inhibition and cytotoxic effects of two different Artemisia spp. (Artemisia dracunculus L. and Artemisia dracunculoides Pursh) cultivated in Türkiye organically, for the first time. The total phenolic and total flavonoid contents of the plants were determined spectrophotometrically while antioxidant activity DPPH•, CUPRAC, and FRAP was determined using the colorimetric method. And also, acetylcholinesterase in vitro enzyme inhibition activity and anti-cancer activity against human melanoma (VMM917, CRL-3232), lung carcinoma (A549, CCL-185), and normal human fibroblast (hGF, PCS-201-018) cells were studied. Total phenolic (225-324 ?g GAE/mL extract) and total flavonoid contents (0.066-0.085 ?g QE/mL extract), antioxidant activity Color Scavenging Concentration 50% (DPPH• (CSC50: 1.371-1.655 mg/mL), CUPRAC (0.246-0.344 ?M CTEAC) and FRAP (462.133-726.661 ?M CTEAC)). A. dracunculus and A. dracunculoides extracts inhibited 40.09 ± 0.65%, and 39.48 ± 3.68% of acetylcholinesterase activity. It was determined that demonstrated the selective effect of A. dracunculus and A. dracunculoides on the cytotoxicity of A549 and hGF cells. According to our results, both tarragon plant species, it may be said that it is not only consumed as food but also used for therapeutic purposes will be beneficial for health.
dc.identifier.doi10.51435/turkjac.1246389
dc.identifier.endpage10
dc.identifier.issn2687-6698
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid1188750
dc.identifier.urihttps://doi.org/10.51435/turkjac.1246389
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188750
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5538
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Analytical Chemistry (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260218
dc.subjectAcetylcholinesterase
dc.subjectArtemisia dracunculus
dc.subjectlung carcinoma
dc.subjectArtemisia dracunculoides
dc.subjecthuman melanoma
dc.titleDetermination of cytotoxic, anti-acetylcholinesterase and antioxidant activity of some medicinal Artemisia spp.
dc.typeArticle

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