Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products

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dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.authoridOpaprakasit, Pakorn/0000-0003-1490-8258
dc.authoridThananukul, Kamonchanok/0000-0003-0714-5694
dc.contributor.authorPutri, Oceu Dwi
dc.contributor.authorPetchsuk, Atitsa
dc.contributor.authorBuchatip, Suthawan
dc.contributor.authorSupmak, Wilairat
dc.contributor.authorKaewsaneha, Chariya
dc.contributor.authorThananukul, Kamonchanok
dc.contributor.authorNim, Bunthoeun
dc.date.accessioned2024-10-04T18:52:41Z
dc.date.available2024-10-04T18:52:41Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA's enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products.en_US
dc.description.sponsorshipThailand Science Research and Innovation Fundamental Fund; Center of Excellence in Materials and Plasma Technology (CoE M@P Tech); Thammasat University; Excellent Foreign Student (EFS) scholarship from SIIT, Thammasat Universityen_US
dc.description.sponsorshipThe authors acknowledge financial support from the Thailand Science Research and Innovation Fundamental Fund and the Center of Excellence in Materials and Plasma Technology (CoE M@P Tech), Thammasat University. O.D.P. is grateful for the scholarship support from the Excellent Foreign Student (EFS) scholarship from SIIT, Thammasat University.en_US
dc.identifier.doi10.1155/2023/9832904
dc.identifier.issn1847-9804
dc.identifier.urihttps://doi.org/10.1155/2023/9832904
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3615
dc.identifier.volume2023en_US
dc.identifier.wosWOS:001051136000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofNanomaterials and Nanotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIn-Vitroen_US
dc.subjectAciden_US
dc.subjectCrystallizationen_US
dc.subjectMicrospheresen_US
dc.subjectCytotoxicityen_US
dc.subjectMorphologyen_US
dc.subjectReleaseen_US
dc.subjectCanceren_US
dc.titlePreparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Productsen_US
dc.typeArticleen_US

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