Analysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic data

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dc.contributor.authorSavrun, Atakan
dc.contributor.authorDirican, Ebubekir
dc.date.accessioned2024-10-04T18:48:14Z
dc.date.available2024-10-04T18:48:14Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractPurpose: Novel coronavirus disease 2019 (COVID-19) is an infectious disease unknown before the 2019 outbreak in Wuhan. This study evaluated telomere length in COVID-19 (+) and (-) samples with clinical-demographic parameters.Materials and Methods: DNA was isolated from COVID-19 (+) (n=70) and (-) (n=70) patients. Telomere length was determined by real-time-PCR (RT-PCR). The 2- increment increment Ct method was used to analyze the telomere length of the samples.Results: There were significant differences in creatinine, LDH, ferritin, WBC, NEU and CRP in COVID-19 (+) patients compared to COVID-19 (-) patients. The NEU/LYM (or N/L) ratio was found higher in the patients with COVID-19 (+), than in COVID-19 (-). On the other hand, our COVID-19 (+) patients (mean +/- std:0.93 +/- 0.58) had significantly shorter telomere lengths than the COVID-19 (-) (mean +/- std:1.26 +/- 0.76). Moreover, COVID-19 (+) male patients (mean +/- std:1.06 +/- 0.50) had longer telomere length than female patients (mean +/- std:0.76 +/- 0.54). Telomere length was significantly shorter in patients with COVID-19 (+) with high blood urea nitrogen (BUN), high creatinine, high hematocrit, high NEU levels, normal platelets (PLT), and low WBC levels.Conclusion: Our findings suggest that telomere length and blood parameter levels influence the severity of COVID-19. Blood parameters differed in patients with COVID-19 (+) and COVID-19 (-). As a result, increasing the number of similar studies in the future can demonstrate the significance of our findings.en_US
dc.identifier.doi10.17826/cumj.1312436
dc.identifier.endpage843en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue3en_US
dc.identifier.startpage833en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1312436
dc.identifier.urihttp://hdl.handle.net/20.500.12403/2982
dc.identifier.volume48en_US
dc.identifier.wosWOS:001117679900031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectTelomere lengthen_US
dc.subjectRT-PCRen_US
dc.subjectNEU/LYMen_US
dc.subjectblooden_US
dc.titleAnalysis of telomere length in patients with COVID-19 and investigation into its relationship with clinical- demographic dataen_US
dc.typeArticleen_US

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