Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin

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dc.contributor.authorCan, Zehra
dc.contributor.authorKara, Yakup
dc.contributor.authorGüler, Halil Ibrahim
dc.contributor.authorBirinci, Ceren
dc.contributor.authorKolaylı, Sevgi
dc.date.accessioned2026-02-28T11:58:24Z
dc.date.available2026-02-28T11:58:24Z
dc.date.issued2023
dc.departmentBayburt Üniversitesi
dc.description.abstractThis study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.
dc.identifier.doi10.51435/turkjac.1390923
dc.identifier.endpage150
dc.identifier.issn2687-6698
dc.identifier.issue2
dc.identifier.startpage143
dc.identifier.trdizinid1222046
dc.identifier.urihttps://doi.org/10.51435/turkjac.1390923
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1222046
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5539
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Analytical Chemistry (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260218
dc.subjectAcetylcholinesterase
dc.subjectAntioxidant Activity
dc.subjectMolecular Docking
dc.subjectUrease
dc.subjectAmygdalin
dc.titleMolecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin
dc.typeArticle

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