Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress

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dc.contributor.authorKarabulut Uzunçakmak, Sevgi
dc.contributor.authorÖzcan, Halil
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorTavacı Özçelik, Ayşegül
dc.date.accessioned2024-10-04T18:58:40Z
dc.date.available2024-10-04T18:58:40Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIntroduction: Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters. Methods: For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions. Results: SOD activity levels were lower in patients than in healthy individuals (p = 0.0309), while the patients’ MDA levels were higher (p = 0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p = 0.1049 and p < 0.0001, respectively). Furthermore, these two genes had a positive correlation among the patients (r = 0.435, p = 0.0025). According to area under the curve (AUC) values, STC-2 (AUC = 0.8332, p < 0.0001) had better diagnostic power than STC-1 (AUC = 0.6167, p = 0.1037). Conclusions: The expression of stanniocalcins in schizophrenia was investigated here for the first time. Decreased STC-2 expression in patients with schizophrenia with increased oxidative stress parameters may guide the understanding of the pathophysiological mechanisms caused by oxidative stress, which may be increased in cognitive diseases such as schizophrenia, and it also has the potential to be a prognostic factor that can be used in the diagnosis of schizophrenia. © 2023 Elsevier Masson SASen_US
dc.identifier.doi10.1016/j.amp.2023.02.005
dc.identifier.issn0003-4487
dc.identifier.scopus2-s2.0-85150428201en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.amp.2023.02.005
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3958
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.relation.ispartofAnnales Medico-Psychologiquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjectSchizophreniaen_US
dc.subjectStanniocalcinen_US
dc.subjectSTC-1en_US
dc.subjectSTC-2en_US
dc.titleEvaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stressen_US
dc.title.alternativeÉvaluation des expressions d'ARNm de STC-1 et STC-2 chez des patients schizophrènes présentant un stress oxydatif accruen_US
dc.typeArticleen_US

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