Molecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalin

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dc.contributor.authorCan, Zehra
dc.contributor.authorKara, Yakup
dc.contributor.authorGüler, Halil İbrahim
dc.contributor.authorBirinci, Ceren
dc.contributor.authorKolaylı, Sevgi
dc.date.accessioned2024-10-04T19:06:31Z
dc.date.available2024-10-04T19:06:31Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThis study investigated that the acetylcholinesterase, urease enzyme inhibition and these enzymes molecular docking as well as antioxidant activity of commercially available amygdalin. While Amygdalin displayed effect anti-urease activity compared to acetohydroxamic acid but, anti-acetylcholine esterase activity a little ineffective compared to donepezil. The molecular docking was performed in order to check binding interactions between the amygdalin and the enzymes. DPPH and FRAP assays were preferred to determine the antioxidant activity. The antioxidant activity (3.39±0.33 µmol Fe2SO47H2O /g, SC50 18.74±0.72 mg/mL using the FRAP and DPPH assays, respectively. Amygdalin's in vitro and in vivo studies are needed for demonstrated that is a therapeutic agent for the treatment of various diseases.en_US
dc.identifier.doi10.51435/turkjac.1390923
dc.identifier.endpage150en_US
dc.identifier.issn2687-6698
dc.identifier.issue2en_US
dc.identifier.startpage143en_US
dc.identifier.trdizinid1222046en_US
dc.identifier.urihttps://doi.org/10.51435/turkjac.1390923
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1222046
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4548
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Analytical Chemistry (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectUreaseen_US
dc.subjectMolecular Dockingen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAmygdalinen_US
dc.titleMolecular docking study on acetylcholinesterase and urease enzyme inhibition effects of Amygdalinen_US
dc.typeArticleen_US

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