Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients

Basit Öğe Kaydı
dc.authoridTakim, Ugur/0000-0003-1108-9437
dc.authoridDirican, Ebubekir/0000-0001-9260-5223
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorOzcan, Halil
dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorTakim, Ugur
dc.date.accessioned2024-10-04T18:49:45Z
dc.date.available2024-10-04T18:49:45Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractObjective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples. Methods: RNA was isolated from the peripheral blood of 39 schizophrenia patients' and healthy samples. After cDNA synthesis, real time PCR (RT-PCR) was used to analyse caspase-3 and caspase-9 gene expression. The severity of psychopathological symptoms of schizophrenia was evaluated using the Positive and Negative Symptoms Scale for schizophrenia (PANSS) and Clinical Global Impressions (CGI). Results: The expression of caspase-3 and caspase-9 genes was higher in schizophrenia patients than in healthy samples (p = 0.012, p = 0.002, respectively). The increase in caspase-3 gene expression was significant with being male, smoking and with a duration of less than 6 years (p = 0.047, p = 0.049, p = 0.034, respectively). On the other hand, the increase in caspase-9 gene expression was significant in patients who is smoke, have children, and are under 33 years old (p = 0.040, p = 0.043, p = 0.045, respectively). A significant positive correlation was detected between the caspase-3 and caspase-9 gene expression (r = 0.3218, p = 0.049). Conclusion: Our findings indicate that caspase-3 and caspase-9 gene expression may activate cell death mechanisms by intrinsic apoptotic genes. Furthermore, caspase-3 and caspase-9 may play essential roles in different ways in schizophrenia. Hence there is a need to further study the apoptotic mechanism with expanded patient populations.en_US
dc.identifier.doi10.9758/cpn.2023.21.1.171
dc.identifier.endpage178en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue1en_US
dc.identifier.pmid36700323en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2023.21.1.171
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3274
dc.identifier.volume21en_US
dc.identifier.wosWOS:000928396500012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology and Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchizophreniaen_US
dc.subjectApoptosisen_US
dc.subjectCaspase-3en_US
dc.subjectCaspase-9en_US
dc.subjectReal time PCRen_US
dc.subjectIntrinsic pathwayen_US
dc.titleEvaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu