The effect of heart failure on gut microbial richness and diversity

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dc.contributor.authorKilic, Oguz
dc.contributor.authorKaya, Halil Ibrahim
dc.contributor.authorSecme, Mucahit
dc.contributor.authorKilinc, Mehmet
dc.contributor.authorSevgican, Cihan Ilyas
dc.contributor.authorBuber, Ipek
dc.contributor.authorDodurga, Yavuz
dc.date.accessioned2024-10-04T18:58:52Z
dc.date.available2024-10-04T18:58:52Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractIntroduction and objective: With recent advances in genome sequencing technology, a large body of evidence has accumulated over the last few years linking alterations in microbiota with cardiovascular disease. In this study, we aimed to compare gut microbial composition using 16S ribosomal DNA (rDNA) sequencing techniques in patients with coronary artery disease (CAD) and stable heart failure (HF) with reduced ejection fraction and patients with CAD but with normal ejection fraction. We also studied the relationship between systemic inflammatory markers and microbial richness and diversity. Methods: A total of 40 patients (19 with HF and CAD, 21 with CAD but without HF) were included in the study. HF was defined as left ventricular ejection fraction <40%. Only stable ambulatory patients were included in the study. Gut microbiota were assessed from the participants’ fecal samples. The diversity and richness of microbial populations in each sample were assessed by the Chao1-estimated OTU number and the Shannon index. Results: The Chao1-estimated OTU number and Shannon index were similar between HF and control groups. There was no statistically significant relationship between inflammatory marker levels (tumor necrosis factor-alpha, interleukin 1-beta, endotoxin, C-reactive protein, galectin-3, interleukin 6, and lipopolysaccharide-binding protein) and microbial richness and diversity when analyzed at the phylum level. Conclusion: In the current study, compared to patients with CAD but without HF, stable HF patients with CAD did not show changes in gut microbial richness and diversity. At the genus level Enterococcus sp. was more commonly identified in HF patients, in addition to certain changes in species levels, including increased Lactobacillus letivazi. © 2023en_US
dc.description.sponsorshipPamukkale Üniversitesi, PAÜ, (2018TIPF005)en_US
dc.identifier.doi10.1016/j.repc.2022.06.016
dc.identifier.endpage551en_US
dc.identifier.issn0870-2551
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85162925468en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage543en_US
dc.identifier.urihttps://doi.org/10.1016/j.repc.2022.06.016
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4063
dc.identifier.volume42en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSociedade Portuguesa de Cardiologiaen_US
dc.relation.ispartofRevista Portuguesa de Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectDiversityen_US
dc.subjectHeart failureen_US
dc.subjectIntestinalen_US
dc.subjectMicrobiotaen_US
dc.titleThe effect of heart failure on gut microbial richness and diversityen_US
dc.title.alternativeO efeito da insuficiência cardíaca estável na riqueza e diversidade microbiana intestinalen_US
dc.typeArticleen_US

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