Determination of the cytotoxic effect of Prangos ferulacea (L.) Lindl. which grows naturally in the foothills of Bayburt Kop Mountain, on non-small lung cancer

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dc.contributor.authorKızıl, Hamit Emre
dc.date.accessioned2026-02-28T11:58:32Z
dc.date.available2026-02-28T11:58:32Z
dc.date.issued2023
dc.departmentBayburt Üniversitesi
dc.description.abstractThe genus Prangos has been used for centuries as an antibacterial and antidiabetic agent. In this study, Prangos ferulacea (L.) Lindl. species, which is frequently encountered in various regions of our country, especially in Northeast Anatolia, and known as \"çaşır or çakşır\" among the people, were collected from the flora of Bayburt Kop Mountain, and methanol extract of the stem parts of this plant was obtained. Afterward, the cytotoxic effect of this extract on the non-small cell lung cancer cell line (H-460) was determined and compared with the cytotoxic activity on the lung fibroblast cell line (MRC-5). The results obtained using the Wst-8 method, it was determined that no toxic effect occurred in the MRC-5 cell line after both 24 and 48 hours of methanol extract treatment, while a toxic effect occurred in the H-460 cell line (125 ?g/ml and 62.5 ?g/ml) after 48 hours of application. However, this toxic effect was not statistically significant.
dc.identifier.doi10.5455/medscience.2023.06.083
dc.identifier.endpage655
dc.identifier.issn2147-0634
dc.identifier.issue3
dc.identifier.startpage652
dc.identifier.trdizinid1259417
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.06.083
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1259417
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5613
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260218
dc.subjectCytotoxicity
dc.subjectlung cancer
dc.subjectMRC-5
dc.subjectPrangos ferulacea (L.) Lindl.
dc.subjectH-460
dc.titleDetermination of the cytotoxic effect of Prangos ferulacea (L.) Lindl. which grows naturally in the foothills of Bayburt Kop Mountain, on non-small lung cancer
dc.typeArticle

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