Relation of ATPase6 Mutations and Telomere Length in Schizophrenia Patients

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dc.authoridTakim, Ugur/0000-0003-1108-9437
dc.authoridDirican, Ebubekir/0000-0001-9260-5223
dc.contributor.authorUzuncakmak, Sevgi Karabulut
dc.contributor.authorDirican, Ebubekir
dc.contributor.authorOzcan, Halil
dc.contributor.authorTakim, Ugur
dc.date.accessioned2024-10-04T18:52:47Z
dc.date.available2024-10-04T18:52:47Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractObjective: Schizophrenia is a serious mental disorder. Mutations in mitochondrial genes can change energy metabolism. Telomere is a tandem sequence at the end of chromosomes. Shorter telomere length has been shown in schizophrenia. The aim of this study was to determine the relationship between ATPase6 gene mutations and telomere length in schizo-phrenia patients.Methods: Blood samples of 34 patients and 34 healthy controls were used. In this study conventional PCR, Sanger sequencing technic and real-time PCR were utilized.Results: Five different mutations (A8860G, A8836, G8697A, C8676T, and A8701G) in the ATPase6 gene were identified in schizophrenia patients. The most seen mutation was A8860G (94%). Telomere length analysis indicated the relation of ATPase6 gene mutations and telomere length variations (p = 0.001). Patients carrying the A8860G mutation had shorter telomere lengths than patients carrying other mutations. Comparing telomere length between schizophrenia pa-tients and healthy controls revealed that the mean telomere length of schizophrenia patients was shorter than healthy controls (p = 0.006). The demographic analysis demonstrated a significant relationship between marital status and telo-mere length (p = 0.011). Besides that, the duration of the illness is another factor that impacts telomere length (p = 0.044). There is no significant relation between telomere length and other clinical and demographic characteristics including education status, age, gender, etc.Conclusion: In conclusion, telomere length and ATPase6 gene mutations have a significant relation. Studies with larger patient populations and investigation of other mitochondrial gene mutations will make the clearer link between telomere length and mitochondrial mutations.en_US
dc.identifier.doi10.9758/cpn.2023.21.1.162
dc.identifier.endpage170en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue1en_US
dc.identifier.pmid36700322en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2023.21.1.162
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3648
dc.identifier.volume21en_US
dc.identifier.wosWOS:000926204600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology and Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectATPase6en_US
dc.subjectMitochondriaen_US
dc.subjectSchizophreniaen_US
dc.subjectTelomereen_US
dc.titleRelation of ATPase6 Mutations and Telomere Length in Schizophrenia Patientsen_US
dc.typeArticleen_US

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