InvestIgatIon of cytotoxIcIty and antIbacterIal effect of boron-contaInIng nano-hydroxyapatIte

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dc.contributor.authorAydın, Numan
dc.contributor.authorKarao?lano?lu, Serpil
dc.contributor.authorKılıç Süloğlu, Aysun
dc.contributor.authorIdil, Neslihan
dc.contributor.authorDemir, Merve
dc.contributor.authorKarakaş, İbrahim Hakkı
dc.date.accessioned2026-02-28T12:09:12Z
dc.date.available2026-02-28T12:09:12Z
dc.date.issued2024
dc.departmentBayburt Üniversitesi
dc.description.abstractIntroduction: Different regenerative materials are used to protect and stimulate pulp tissue. Objectives: This in vitro study aimed to examine the cytotoxicity of different doses of boron-containing nano-hydroxyapatite (B-nHAp) and its antibacterial effect. Material and methods: B-nHAp was synthesized with microwave-assisted chemical precipitation method at different rates, such as 1%, 5%, and 10%. The extracts were prepared in separate tubes: 1%, 5%, 10% B-nHAp, and nHAp 50 mg/ml. Cytotoxicity test was performed on L929 mouse fibroblasts for 24 and 72 hours. Antibacterial analysis was performed with Streptococcus mutans bacteria using micro-dilution method. Cell viability values were evaluated with two-way analysis of variance (ANOVA) test (p < 0.05). Results: B-nHAp was successfully synthesized in XRD and SEM analyses. Nano-hydroxyapatite showed more cell viability than control group at 24 and 72 hours. All B-nHAp extracts demonstrated less cell viability at the end of 24 hrs. than control group. However, 1% B-nHAp cell viability decreased more in the B-nHAp group compared with the control group, while 5% and 10% B-nHAp showed high cell viability after 72 hours of incubation. B-nHAp demonstrated less antibacterial effect on Streptococcus mutans compared with nHAp. Conclusions: According to the results, the addition of boron to nano-hydroxyapatite does not make a significant contribution to increase the regenerative and antibacterial properties of the material. © 2024 Polish Dental Association.
dc.identifier.doi10.5114/jos.2024.139890
dc.identifier.endpage99
dc.identifier.issn00114553
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85195651302
dc.identifier.scopusqualityQ4
dc.identifier.startpage93
dc.identifier.urihttps://doi.org/10.5114/jos.2024.139890
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5873
dc.identifier.volume77
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTermedia Publishing House Ltd.
dc.relation.ispartofJournal of Stomatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260218
dc.subjectboron
dc.subjectcytotoxicity
dc.subjectnano-hydroxyapatite
dc.subjectStreptococcus mutans
dc.titleInvestIgatIon of cytotoxIcIty and antIbacterIal effect of boron-contaInIng nano-hydroxyapatIte
dc.typeArticle

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