Could eumelanin molecule from Streptomyces parvus BSB49 strain be a potential anticancer agent for lung cancer?

Basit Öğe Kaydı
dc.contributor.authorKızıl, Hamit Emre
dc.contributor.authorBayram, Sinan
dc.contributor.authorOzturk, Serdar
dc.contributor.authorKarakas, Umit
dc.date.accessioned2024-10-04T19:04:13Z
dc.date.available2024-10-04T19:04:13Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractMelanins, which are divided into five different subgroups as eumelanin, pheomelanin, allomelanin, neuromelanin and pyomelanin, are a heterogeneous and amor- phous biopolymer family. Although melanin is produced in many different ways today, it is more practical, and more economical to produce melanin using bacterial strains. The eumelanin pigment, which is the subject of this study, was obtained using Streptomyces parvus BSB49 strain, and its antiproliferative effect at various concentrations against small cell (DMS-114) and non-small cell (H-460) lung cancer was determined. According to our results, the synthesized eumelanin molecule was statistically cytotoxic on non-small cell lung cancer cell line (H-460) at concentrations of 3.125 and 1.56 ?g/mL after 24 hours of treatment (IC50=8 ?g/mL) and only at a concentration of 3.125 ?g/mL after 48 hours of treatment (IC50=8.4 ?g/mL). In the small cell lung cancer cell line (DMS-114), no statistically cytotoxic concentration was detected (p<0.05).en_US
dc.identifier.doi10.5455/medscience.2023.08.131
dc.identifier.endpage1192en_US
dc.identifier.issn2147-0634
dc.identifier.issue4en_US
dc.identifier.startpage1189en_US
dc.identifier.trdizinid1261381en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.08.131
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1261381
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4246
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEumelaninen_US
dc.subjectH-460en_US
dc.subjectDMS-114en_US
dc.subjectlung canceren_US
dc.titleCould eumelanin molecule from Streptomyces parvus BSB49 strain be a potential anticancer agent for lung cancer?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu