C626G Polymorphism in the Apoptotic Death Receptor-4 TRAIL Binding Domain Associated with Recurrent Pregnancy Loss: Case-Control Research

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dc.contributor.authorTekin, Sevinç Sürer
dc.contributor.authorAy, Mustafa Ertan
dc.contributor.authorDurukan, Hüseyin
dc.contributor.authorÇevik, Kenan
dc.contributor.authorIzciay, Özlem
dc.contributor.authorÖzdemir, Gurbet Doğru
dc.contributor.authorKarakaş, Ümit
dc.date.accessioned2024-10-04T18:58:37Z
dc.date.available2024-10-04T18:58:37Z
dc.date.issued2021
dc.departmentBayburt Üniversitesien_US
dc.description.abstractObjective: Disruption of apoptotic balance in cells during embryonic development can lead to pregnancy losses. In this study, the relationship between unexplained recurrent pregnancy loss (RPL) and apoptotic inducing death receptor-4 (DR-4) gene polymorphisms was investigated. Material and Methods: In this study, genomic DNA was obtained from 70 women diagnosed with RPL and 70 women as a control group. The polymorphisms of rs6557634 G422A in the 3rd exon of the DR-4 gene, rs20575 C626G in the 4th exon and rs20576 A683C in the 5th exon were determined in both groups using the polyme rase chain reaction-restriction fragment length polymorphism method. Results: It was determined that the incidence of C626G polymorphism, which is a missense variant in exon 4 resulting in the change of threo-nine to arginine in the 209th codone in the extracellular TRAIL ligand binding domain of DR-4, increased in RPL cases compared to the con-trols. For the investigated exon 3 and exon 5 polymorphisms, no statistical difference was observed between the RPL and the control group. Conclusion: We conclude that the missense exon 4 polymorphism in the DR-4 gene, which we detected in patients with RPL, may cause pregnancy losses through the invasion of the embryo to the uterus during embryonic development and the disruption of the apoptotic balance in its immunological tolerance. © 2021 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2021-83700
dc.identifier.endpage484en_US
dc.identifier.issn1300-0292
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85123254398en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage478en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2021-83700
dc.identifier.urihttp://hdl.handle.net/20.500.12403/3923
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectDeath receptor-4en_US
dc.subjectPolymorphismen_US
dc.subjectRecurrent pregnancy lossen_US
dc.subjectTRAILen_US
dc.titleC626G Polymorphism in the Apoptotic Death Receptor-4 TRAIL Binding Domain Associated with Recurrent Pregnancy Loss: Case-Control Researchen_US
dc.title.alternativeTekrarlayan Gebelik Kaybı ile İlişkili Apoptotik Ölüm Reseptörü-4 TRAIL Bağlanma Bölgesindeki C626G Polimorfizmi: Vaka-Kontrol Araştırmasıen_US
dc.typeArticleen_US

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