Determination of Cytotoxic and Apoptotic Properties of Lobaric Acid, a Secondary Metabolite of Lichen and Investigation of Its Theoretical Potential

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dc.contributor.authorKızıl, Hamit Emre
dc.contributor.authorAgar, Guleray
dc.contributor.authorEkincioğlu, Yavuz
dc.date.accessioned2026-02-28T11:58:33Z
dc.date.available2026-02-28T11:58:33Z
dc.date.issued2024
dc.departmentBayburt Üniversitesi
dc.description.abstractIn this study, we aimed to elucidate some of the mechanisms of cell death induced by lobaric acid in A549 (human lung cancer) cells. For this purpose, the effects of cytotoxic concentrations on p53 and caspase-3 gene expressions were investigated. A549 cells were treated with varying concentrations of lobaric acid (12.5, 25, 50, and 100 µg/ml) for 48 hours and then their viability was evaluated and p53 and caspase-3 mRNA expressions were determined at statistically cytotoxic concentrations of 12.5, 50, and 100 µg/ml. According to beta-actin, it was determined that the increase in lobaric acid concentration revealed an upward trend in p53 and caspase-3 mRNA expressions. Furthermore, quantum chemical parameters such as frontier molecular orbitals, band gap energy and ionization potential, electronic affinity, chemical softness, chemical potential, electrophilicity index and chemical hardness were analyzed. Furthermore, molecular docking was performed to identify the binding sites and the binding behavior of lobaric acid to some target proteins (P53, Caspase-3 and Bcl-2).
dc.identifier.doi10.56430/japro.1518450
dc.identifier.endpage200
dc.identifier.issn2757-6620
dc.identifier.issue3
dc.identifier.startpage192
dc.identifier.trdizinid1270759
dc.identifier.urihttps://doi.org/10.56430/japro.1518450
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1270759
dc.identifier.urihttps://hdl.handle.net/20.500.12403/5633
dc.identifier.volume5
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of agricultural production (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260218
dc.subjectMolecular docking
dc.subjectCytotoxicity
dc.subjectApoptosis
dc.subjectLobaric acid
dc.titleDetermination of Cytotoxic and Apoptotic Properties of Lobaric Acid, a Secondary Metabolite of Lichen and Investigation of Its Theoretical Potential
dc.typeArticle

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