ANTIBACTERIAL, ANTIFUNGAL, ANTIBIOFILM, ANTIOXIDANT, AND ANTICANCER PROPERTIES OF METHANOL EXTRACTS OF SOME ACANTHOLIMON BOISS (PLUMBAGINACEAE) SPECIES

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dc.contributor.authorBostancı, Maside Temiz
dc.contributor.authorBülbül, Ali Savaş
dc.contributor.authorUygun, Cihangir
dc.contributor.authorBekmezci, Muhammed
dc.contributor.authorBayat, Ramazan
dc.contributor.authorŞen, Fatih
dc.date.accessioned2024-10-04T19:04:05Z
dc.date.available2024-10-04T19:04:05Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractTherapeutic properties of plants have been used since the existence of mankind. To benefit from this feature, the discovery of the active components of plants has gained momentum today. One of these plant species is Acantholimon Boiss. This plant extract has antifungal, antimicrobial, and anticancer properties. In this article, antimicrobial, antifungal and antioxidant capacities and antibiofilm properties of Acantholimon Boiss plant extract on 15 bacterial and 2 fungal species were evaluated. Antimicrobial properties were evaluated by Agar Well Diffusion method. It was observed that the plants formed a zone diameter of 12-18 cm. Minimum Inhibition Concentration (MIC) and Minimum Bactericidal Concentration (MBC) tests were used to determine the minimum active property. Biofilms of almost all bacteria were reduced by 10-50% by Acantholimon species at doses of 8 mg/ml-16 mg/ml. For MCF-7 cells, the IC50 values for A. acerosum subsp. brachystachyum (Boiss. ), A. acenum var. balansae, A. armenum var. balansae and A. kotschyi were 0.143 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml, 0.63 mg/ml and 0.107 mg/ml, respectively. The same doses did not show a cytotoxic effect on HUVEC cell lines. With this article, it has given important results in terms of having a wide range of bacterial studies and examining its activities in fungi and cell lines. These findings suggest that extracts of Acantholimon Boiss species may be a potential source of natural medicines and antibacterial, antifungal, antibiofilm, antioxidant, and anticancer activities may support their therapeutic use.en_US
dc.identifier.doi10.59313/jsr-a.1296378
dc.identifier.endpage163en_US
dc.identifier.issn2687-6167
dc.identifier.issue54en_US
dc.identifier.startpage149en_US
dc.identifier.trdizinid1201705en_US
dc.identifier.urihttps://doi.org/10.59313/jsr-a.1296378
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1201705
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4163
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of scientific reports-A (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcantholimon speciesen_US
dc.subjectAnticancer activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.titleANTIBACTERIAL, ANTIFUNGAL, ANTIBIOFILM, ANTIOXIDANT, AND ANTICANCER PROPERTIES OF METHANOL EXTRACTS OF SOME ACANTHOLIMON BOISS (PLUMBAGINACEAE) SPECIESen_US
dc.typeArticleen_US

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