Ultrasonicate-assisted preparation of eumelanin-loaded nano/microparticles based on polylactide stereocomplex

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dc.contributor.authorPutri, Oceu Dwi
dc.contributor.authorPetchsuk, Atitsa
dc.contributor.authorBayram, Sinan
dc.contributor.authorOpaprakasit, Pakorn
dc.date.accessioned2024-10-04T18:58:54Z
dc.date.available2024-10-04T18:58:54Z
dc.date.issued2022
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe utilization of ultrasonication in the preparation of polymeric nano/microparticles has attracted vast attention due to its simplicity with low cost and high energy efficiency. The occurrence of acoustic cavitation generated by the ultrasonication process can enhance droplet disintegration, allowing the improved stability of emulsions. In this study, eumelanin-loaded nano/microparticles were prepared by employing polylactide stereocomplex (sc-PLA) formed by blending of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), triblock copolymer with linear poly(L-lactide), PLLA. The particles were prepared through an oil in water emulsion (O/W) technique followed by a solvent evaporation. The effect of ultrasonication on the encapsulation efficiency and physicochemical properties of the nano/microparticles was evaluated. The results showed that ultrasonication treatment could control nano/microparticles' shape, size, and size distribution, which enhanced the particle stability and the entrapment efficiency of eumelanin. Particle size distribution of ultrasound-assisted nano/microparticles was in a range of 0.38–135 ?m, while those without ultrasonication had a broader distribution from 0.38–153 ?m. Higher zeta potential was also observed in the ultrasound-assisted nano/microparticles, reflecting their higher suspension stability. The ultrasonication treatment led to higher eumelanin encapsulation efficiency (46.6%) with higher thermal stability and crystallinity, promoted by the formation of higher contents of the stereocomplex crystallites. The results confirm that ultrasonicate-assisted emulsification can be effectively used to fabricate the functional eumelanin-loaded nano/microparticles. © 2022en_US
dc.description.sponsorshipCenter of Excellence in Materials and Plasma Technology; Sirindhorn International Institute of Technology; Thammasat University, Thailand; Thammasat University, TUen_US
dc.identifier.doi10.1016/j.matpr.2022.07.088
dc.identifier.endpage3030en_US
dc.identifier.issn2214-7853
dc.identifier.scopus2-s2.0-85135187518en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3025en_US
dc.identifier.urihttps://doi.org/10.1016/j.matpr.2022.07.088
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4079
dc.identifier.volume66en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Today: Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEncapsulationen_US
dc.subjectEumelaninen_US
dc.subjectPolylactideen_US
dc.subjectStereocomplexen_US
dc.titleUltrasonicate-assisted preparation of eumelanin-loaded nano/microparticles based on polylactide stereocomplexen_US
dc.typeConference Objecten_US

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