Highly Enantioselective Production of Chiral Secondary Alcohols with Candida zeylanoides as a New Whole Cell Biocatalyst

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dc.authorid0000-0002-3723-1705en_US
dc.contributor.authorŞahin, Engin
dc.contributor.authorDertli, Enes
dc.date.accessioned2020-11-25T19:10:35Z
dc.date.available2020-11-25T19:10:35Z
dc.date.issued2017en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThe increasing demand for biocatalysts in synthesizing enantiomerically pure chiral alcohols results from the outstanding characteristics of biocatalysts in reaction, economic, and ecological issues. Herein, fifteen yeast strains belonging to three food originated yeast species Candida zeylanoides, Pichia fermentans, and Saccharomyces uvarum were tested for their capability for asymmetric reduction of acetophenone to 1‐phenylethanol as biocatalysts. Of these strains, C. zeylanoides P1 showed an effective asymmetric reduction ability. Under optimized conditions, substituted acetophenones were converted to corresponding optically active secondary alcohols in up to 99% enantiomeric excess and at high yields. The preparative scale asymmetric bioreduction of 4‐nitroacetophenone (1m) by C. zeylanoides P1 gave (S)‐1‐(4‐nitrophenyl)ethanol (2m) with 89% yield and > 99% enantiomeric excess. Compound 2m has been obtained in an enantiomerically pure and inexpensive form. Additionally, these results indicate that C. zeylanoides P1 is a promising biocatalyst for the synthesis of chiral alcohols in industry.en_US
dc.identifier.citationŞahin, E., & Dertli, E. (2017). Highly enantioselective production of chiral secondary alcohols with Candida zeylanoides as a new whole cell biocatalyst. Chemistry & biodiversity, 14(9), e1700121.en_US
dc.identifier.doi10.1002/cbdv.201700121
dc.identifier.endpagee1700121en_US
dc.identifier.issue9en_US
dc.identifier.pmid28746771en_US
dc.identifier.scopus2-s2.0-85028615054en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpagee1700121en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.201700121?casa_token=sUFjni58omMAAAAA%3A9Y6AUm5RT0JVgqHSjcuO0MtUQ9iUGClA0LlMDUWHtGNSXMvj9PIPQXCPkUfRtDvf2J_3DBo3ZBedLClN
dc.identifier.urihttps://hdl.handle.net/20.500.12403/2218
dc.identifier.volume14en_US
dc.identifier.wosWOS:000410558700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChemistry Biodiversityen_US
dc.relation.ispartofChemistry Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectBiotransformationen_US
dc.subjectchiralityen_US
dc.titleHighly Enantioselective Production of Chiral Secondary Alcohols with Candida zeylanoides as a New Whole Cell Biocatalysten_US
dc.typeArticleen_US

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