Determination of the cytotoxic effect of Prangos ferulacea (L.) Lindl. which grows naturally in the foothills of Bayburt Kop Mountain, on non-small lung cancer

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dc.contributor.authorKızıl, Hamit Emre
dc.date.accessioned2024-10-04T19:05:18Z
dc.date.available2024-10-04T19:05:18Z
dc.date.issued2023
dc.departmentBayburt Üniversitesien_US
dc.description.abstractThe genus Prangos has been used for centuries as an antibacterial and antidiabetic agent. In this study, Prangos ferulacea (L.) Lindl. species, which is frequently encountered in various regions of our country, especially in Northeast Anatolia, and known as \"çaşır or çakşır\" among the people, were collected from the flora of Bayburt Kop Mountain, and methanol extract of the stem parts of this plant was obtained. Afterward, the cytotoxic effect of this extract on the non-small cell lung cancer cell line (H-460) was determined and compared with the cytotoxic activity on the lung fibroblast cell line (MRC-5). The results obtained using the Wst-8 method, it was determined that no toxic effect occurred in the MRC-5 cell line after both 24 and 48 hours of methanol extract treatment, while a toxic effect occurred in the H-460 cell line (125 ?g/ml and 62.5 ?g/ml) after 48 hours of application. However, this toxic effect was not statistically significant.en_US
dc.identifier.doi10.5455/medscience.2023.06.083
dc.identifier.endpage655en_US
dc.identifier.issn2147-0634
dc.identifier.issue3en_US
dc.identifier.startpage652en_US
dc.identifier.trdizinid1259417en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.06.083
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1259417
dc.identifier.urihttp://hdl.handle.net/20.500.12403/4289
dc.identifier.volume12en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrangos ferulacea (L.) Lindl.en_US
dc.subjectlung canceren_US
dc.subjectH-460en_US
dc.subjectMRC-5en_US
dc.subjectcytotoxicityen_US
dc.titleDetermination of the cytotoxic effect of Prangos ferulacea (L.) Lindl. which grows naturally in the foothills of Bayburt Kop Mountain, on non-small lung canceren_US
dc.typeArticleen_US

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