Phytochemical profile, antioxidant potential, and cytotoxic effect of the ethanol extract of Micromeria fruticosa

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dc.contributor.authorÇakır, Özlem
dc.contributor.authorTopcu, Kübra Cinar
dc.contributor.authorAnlar, Pınar
dc.date.accessioned2026-09-01T15:50:26Z
dc.date.available2026-09-01T15:50:26Z
dc.date.issued2026
dc.departmentBayburt Üniversitesi
dc.description.abstractIn this study, the ethanol extract of dried Micromeria fruticosa (L.) Druce, commercially sourced from the Tortum Valley (Erzurum Province), was comprehensively analysed to evaluate its bioactive potential. Considering that geographical origin and botanical differences significantly influence phytochemical composition and biological activity, the use of locally sourced commercial samples provides valuable data for plant standardisation and comparative studies. The total antioxidant activity of the extract was determined as 8.84±0.10, 4.96 ±0.05, 34.64 ±0.69, and 18.27 ±0.11 mg TE/g dry weight by DPPH, FRAP, CUPRAC, and ABTS assays, respectively. The total phenolic content was 26.25 mg GAE/g dry weight, and LC-MS/MS analysis revealed a high quinic acid content (93.395 mg/g). ICP-MS analysis showed high levels of essential minerals (Na, Mg, K, Ca, Fe, and Al), while toxic elements such as Cd, Te, and Tl were below the limit of detection, and Pb and Ba were present at very low concentrations. Additionally, the extract significantly reduced A549 lung cancer cell viability in a dose-dependent manner. Overall, Tortum Valley–derived M. fruticosa represents a promising natural bioactive source, and this study highlights the impact of local botanical and environmental variations on the biological activity of the same plant species.
dc.identifier.doi10.3153/FH26018
dc.identifier.endpage235
dc.identifier.issn2602-2834
dc.identifier.issue3
dc.identifier.startpage224
dc.identifier.trdizinid1451285
dc.identifier.urihttps://doi.org/10.3153/FH26018
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1451285
dc.identifier.urihttps://hdl.handle.net/20.500.12403/8405
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofFood and Health
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20260820
dc.subjectGıda Bilimi ve Teknolojisi
dc.subjectBitki Bilimleri
dc.titlePhytochemical profile, antioxidant potential, and cytotoxic effect of the ethanol extract of Micromeria fruticosa
dc.typeArticle

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