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Öğe Adipokine, gut and thyroid hormone responses to probiotic application in chukar partridges (Alectoris chukar) exposed to heat stress(Akademiai Kiado Zrt, 2021) Bayraktar, Bulent; Tekce, Emre; Kaya, Hacer; Gurbuz, Ahmet Burak; Dirican, Ebubekir; Korkmaz, Serol; Atalay, BanuThe aim of this study was to investigate the effect of Lactobacillus reuteri E81 (LRE) probiotic supplementation on heat stress responses in chukar partridges (Alectoris chukar). The birds were divided into two groups, one of which was exposed to heat stress (HS). Within each group, four subgroups, each including 64 birds, were created for the three treatment doses (200, 400 or 600 mg/kg) of LRE and the control. The experiment was started with day-old birds, kept at a temperature of 25 degrees C or 37 degrees C. After a 7-day adjustment period, the LRE supplementation lasted for 35 days. The levels of different adipokines, including visfatin (VF), adiponectin (ADP), chemerin (CHEM), as well as the concentration of plasma citrulline (CIT) and the levels of thyroid hormones (T3 and T4) and thyroid-stimulating hormone (TSH) in the blood were measured at 21 and 42 days of age. A significant correlation (P < 0.01) was found between LRE supplementation and the decrease in serum VF, ADP, CIT, T3 and T4 levels in partridges exposed to HS. On the other hand, no significant relationship was found between LRE supplementation and the serum CHEM and TSH levels (P > 0.05). We concluded that the addition of 600 mg/kg LRE is beneficial in preventing intestinal damage and inflammation provoked by HS.Öğe Effect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats(Agricultural Research Communication Centre, 2025) Orkun Erkilic, Tugce; Bayraktar, BulentBackground: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein ( Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.Öğe Emotion regulation skills, brain-derived neurotrophic factor, cortisol hormone levels in primary school students in Turkiye: a cross-sectional and correlational analysis study(Bmc, 2025) Kirbas, Zila Ozlem; Bayraktar, Bulent; Aktas, Elif OdabasiBackground Hormones are molecules that contribute significantly to mental and physical health due to their role in emotion regulation (ER) processes. However, the role and effect of hormones on the ER has not yet been fully elucidated. In this study, it was aimed to examine the salivary Brain-derived neurotrophic factor (BDNF) and cortisol hormone response to support ERS in primary school students depending on some parameters. Method This cross-sectional and correlational study was conducted in the Eastern Black Sea Region of Turkiye between April 2023 and June 2023. In the sample selection, after the number of students was determined in proportional stratification, the sample selection method was made by simple random selection from each class list, first according to the school and then the grade level of each school. A total of 177 healthy students between the ages of 8 and 10 who attended these schools, were allowed to participate in the research by their families, and were volunteers, were included in the study. Data were collected using the Personal Information Form and the Emotion Regulation Scale for Children and saliva collection cups. Human-specific Brain-derived neurotrophic factor ELISA Kit (BT LAB, Cat.No E1302Hu, CHINA) for measuring BDNF levels in saliva; In measuring the level of cortisol hormone in saliva, Human Cortisol ELISA Kit (BT LAB, Cat.No E 1 003Hu, CHINA) was used in accordance with the procedure specified in the manufacturer's catalogue. Data were evaluated using the SPSS 26.0 for Windows (SPSS, Chicago, Il, USA) package program. Independent Samples Test and One-Way ANOVA test, correlation and Multiple Linear Regression analysis were used to evaluate the data. P <.01 and p <.05 significance levels were used as statistical significance values. Results A statistically significant correlation was found between the mean total score of the Emotion Regulation Skills Scale for Children and the mean level of salivary BDNF, and a negative correlation between the mean level of salivary cortisol (p<0.01). Conclusions Within the scope of the data obtained in our current study, BDNF levels were found to be high and cortisol hormone levels to be low in children with high ERS.Öğe Eugenol alleviates the negative effects of experimental periodontitis and regulates adipokine hormones in rats(Elsevier, 2024) Gul, Sema Nur Sevinc; Eminoglu, Didem Ozkal; Tekce, Emre; Bayraktar, Bulent; Guven, Leyla; Dilsiz, Alparslan; Yildrim, SerkanA chronic microbial infection that is mediated by the host's immune system is the cause of periodontal disease. As the world's population grows, phytotherapy is a therapeutic strategy that makes use of a renewable resource that can provide less costly medicines. This study aimed to investigate the therapeutic effects of eugenol administration on periodontitis by examining the effects of eugenol at different doses biochemically, histopathologically, and radiologically in rats with experimental periodontitis. Thirty-two Sprague Dawley male rats were divided into four groups: 1. the healthy control group (CG), 2. The experimental periodontitis group (PG), 3. The experimental periodontitis+10 mg/kg eugenol group (EG10), and 4. the experimental periodontitis+20 mg/kg eugenol group (EG20). Alveolar bone loss was measured using micro-CT imaging. The TNF-alpha, IL-6, leptin, asprosin, and apelin levels were analyzed in the serum samples of rats. Histological and immunohistochemical analyses were performed. The data were analyzed statistically. The serum TNF-alpha, IL-6, leptin, asprosin, and apelin levels were found to be statistically significantly lower in the eugenol-applied groups (EG10 and EG20) than in the PG (p < 0.05). There was a statistically significant difference in the TNFa, IL-6, leptin, asprosin, and apelin levels between the EG10 and EG20 (p < 0.05). In the measurements made using micro-CT imaging, alveolar bone loss was found to be at the lowest FR1 level, and in histopathological analysis, the least inflammation was observed in the EG20. It was concluded that the application of 20 mg/kg eugenol in rats with experimental periodontitis was a safe dose, was beneficial in alleviating bone loss, and had a positive effect on the healing process. (c) 2024 SAAB. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Öğe Investigation of emotion regulation skills, salivary apelin, and serotonin levels in children in Turkiye: a cross-sectional study(Taylor & Francis Ltd, 2024) Kirbas, Zila Ozlem; Bayraktar, Bulent; Aktas, Elif OdabasiPurpose: Little is known about the relationship between apelin and serotonin in emotion regulation. This study aimed to examine children's emotional regulation skills and salivary apelin and serotonin levels. Methods: This is a cross-sectional study performed in Turkiye. The research was completed with the participation of 146 children, 8-10 years old, from the general population. Emotion Regulation Skills Scale for Children (CERS) was used to assess children's levels of emotion regulation skills. Apelin and serotonin levels were examined by ELISA technique in saliva samples obtained from children. Results: A statistically significant correlation was found between the mean total score of the CERS and the mean apelin and serotonin levels (p < .01). We found that females had higher emotion regulation skills compared to males, older higher than younger ones (p < .01). The regression analysis results show that age and gender together explain 50.5% of the variance in CERS scores, while apelin and serotonin together explain 35.8% of the variance. When all four variables (age, gender, apelin, and serotonin) are included in the model, they explain 51.3% of the variance in CERS scores. Conclusion: Older age and female gender explained most of emotion regulations skills.Öğe Investigation of endocrine and cerebral response and nutrition and physical performance parameters according to bigorexia nervosa levels: a cross-sectional study in sports sciences faculty students(Nature Portfolio, 2025) Erkilic, Ali Ozan; Bayraktar, Bulent; Erkilic, Tugce Orkun; Turkmen, Mutlu; Kul, Murat; Yonal, MehmetThe aim of this study is to investigate the effects of Bigorexia nervosa (BGN) levels on endocrine (Asprosin, GLP-1) and cerebral (BDNF) responses and nutritional and physical (6MWT, Six-Minute Walk Test)), speed, metabolic equivalent unit (MET)) performance parameters in students of the faculty of sports sciences. This study investigated muscle dysmorphic disorder (MDD), physical activity levels, and specific hormonal markers in 120 university students (63 females, 57 males) aged 18-25 years, all studying sport sciences and reporting no existing health problems. Participants completed a demographic questionnaire, food frequency questionnaire and the Muscle Dysmorphic Disorder (Bigorexia) Inventory through face-to-face interviews. Physical activity was assessed using the 6-Minute Walk Test (6MWT) to measure walking distance, and Metabolic Equivalent (MET) was calculated based on the American College of Sports Medicine (ACSM) formula. Body Mass Index (BMI) was determined from anthropometric measurements of height and body weight. Saliva samples were collected to analyze Asprosin, BDNF, and GLP-1 hormone levels using the ELISA technique.Data were analyzed using number, percentage, mean, chi-square, t-test, Pearson correlation, and ANOVA tests. In all analyses, significance was accepted as p < 0.05. According to the demographic findings of the study, the majority of participants (64.2%) were third-year students, and 52.5% were female. The mean age of the participants was 22.01 years, the mean height was 168.59 cm, and the mean weight was 62.61 kg. 73.3% of the individuals were classified as normal weight, 12.5% as pre-obese, 11.7% as underweight, and 2.5% as obese. Men had significantly higher bigorexia and its subscale scores than women (p < 0.05), and bigorexia was positively correlated with height and negatively correlated with BMI (p < 0.01). Mean salivary BDNF levels were higher in participants consuming 1-2 meals per day (p = 0.035), and mean salivary asprosin levels were significantly higher in the obese group compared to the healthy group (p = 0.008). Additionally, a strong positive correlation was found between asprosin and GLP1 levels (r = 0.585; p < 0.01). Bigorexia status was significantly associated with meat, meat products, and fat consumption (p < 0.05), while no association was found with physical performance parameters such as 6MWT, speed, and MET (p > 0.05). The average MET value was found to be 4.53, indicating that participants generally engaged in moderate-intensity physical activity. In conclusion, examining endocrine (asprosin, GLP-1) and cerebral (BDNF) hormone responses, as well as nutritional and physical performance parameters, according to BGN levels reveals the impact of BGN on physiological and nutritional behaviors. Given the impact of BGN trends on students' health, examining hormone profiles and their relationships with physical performance and nutrition is believed to significantly contribute to understanding the health problems associated with BGN and developing appropriate interventions.Öğe Investigation of endocrine response of thyroid and intestinal and adipose tissues due to the addition of Moringa oleifera essential oil in diet for quails exposed to heat stress(Revista Brasileira Zootecnia Brazilian Journal Animal Sci, 2023) Bayraktar, Bulent; Tekce, Emre; Bayraktar, Sevil; Boyuk, Gulbahar; Takma, Cigdem; Aksakal, Vecihi; Genc, Murat-In this study, we aimed to determine the effect of Moringa oleifera essential oil (MOEO) supplementation to rations of Japanese quail (Coturnix coturnix japonica) grown under heat stress (HS) on some adipokine (visfatin, adiponectin, and chemerin), intestinal (citrulline), 3,5,3 '-triiodothyronine (T3), thyroxine (T4), and thyroid-stimulation hormone (TSH) levels in the serum. For this purpose, 320 day-old male quail chicks were used. The study was conducted over 42 days, including a 7-d adaptation period and a 35-d experimental period. Eight trial groups were established, each including 10 quail: CT (control temperature, 25 celcius), MOEO 200, MOEO 400, MOEO 600, HSC (HS control), SMOEO 200, SMOEO 400, and SMOEO 600. Based on the results, a dose-dependent decrease was observed on days 21 and 42 in serum adiponectin and T3 in the stress and stress-free groups compared with the control group due to MOEO supplementation. The lowest decrease was observed in the MOEO 600 mg/kg dose group. In addition, an increase in stressed groups was observed when examining serum citrulline levels, while chemerin levels did not have a statistically significant effect. While the decrease in serum visfatin, T4, and TSH levels on the 21st day did not have a statistically significant effect, a significant effect was determined on the 42nd day. The addition of MOEO at 600 mg/kg to the ration may be beneficial in preventing intestinal damage and inflammation that may occur due to HS.Öğe Investigation of the recovery efficiency of CeUF method through RT-qPCR quantification of inactivated SARS-CoV-2 in untreated wastewater(Elsevier Science Inc, 2022) Sait, Ahmet; Korkmaz, Serol; Parmaksiz, Ayse; Bayraktar, BulentWastewater-based disease monitoring is an early warning system and a surveillance tool for infectious disease outbreaks regarding pathogens with pandemic potential. This study aimed at investigating the recovery efficiency of centrifugal ultrafiltration (CeUF), which is one of the most-used virus concentration methods, for inactive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) added to wastewater. Inactivated SARS-CoV-2 was inoculated into untreated wastewater at different concentrations (4 x 10(3), 8 x 10(3), 16 x 10(3), 24 x 10(3) and 32 x 10(3) gene copy/mu L) and concentrated through ultrafiltration with a disposable centrifugal filter device. Total nucleic acids in concentrated filtrates were extracted and isolated by an automated system. In isolates, total RNA was measured by a UV/VIS spectrophotometer, and the recovered virus was quantified by RT-qPCR with two gene regions (N1 and N2). The recovery rates were between 11% and 17.8% (mean 15.1%, CV below 15%). While there were positive correlations among the inoculated virus, total RNA and recovered virus, there was no correlation and linearity between the recovery rates. Despite limited recovery rates, CeUF integrated with RT-qPCR quantification can be a valid assay for monitoring SARS-CoV-2 in wastewater, and an early warning system.Öğe Investigation of the relationship of asprosin and cardiac troponin response with some physiological and biochemical parameters in Anatolian native horse(Hippiatrika Verlag Mbh, 2021) Bayraktar, Bulent; Tekce, EmreAsprosin is a recently discovered glucogenic hormone released from starvation-induced white adipose tissue and amongst others it protects against hyperinsulinism associated with metabolic syndrome. The aim of this study was to examine the effect of age, gender and season on metabolic (asprosin) and cardiovascular (cardiac troponin, I (cTnI), CK, CK-MB) function markers and their relationship with some biochemical parameters in Anatolian native horse breed. This study was carried out between February-August 2020. A total of 40 horses was used for this purpose, including 20 mares and 20 stallions in the age range of 1-6, 7-12. Serum asprosin level, for the winter season in stallions and mares aged 1-6 and 7-12 years respectively 8.9, 8.36; 14.08, 13.58 ng/ml were as determined. In addition, for the summer season respectively 17.98, 18.68; 22.22, 21.32 ng/ml were detected and no difference between the groups (P>0.05). On the other hand, serum cTnI levels for the winter season in stallions and mares aged 1-6 and 7-12 years respectively 0.014, 0.018; 0.016, 0.02 ng/ml were as determined. In addition, for the summer season respectively 0.012, 0.016; 0.014, 0.018 ng/ml were detected. It was shown that the serum biochemical parameters and levels of cTnI levels in the domestic horse breed the horses belonging to the Anatolian varied depending on age, gender, and season (p < 0.05) but the effect of hormone levels serum asprosin wasn't found statistically significant (p>0.05).Our results showed that cTnI could be a useful parameter in the examination of the cardiovascular system status of horses.Öğe Preventive and therapeutic effects of the peel powder of P. granatum in a rat sepsis model(Univ Zagreb Vet Faculty, 2023) Ulker, Ufuk; Demirel, Murside Ayse; Bayraktar, Bulent; Alcigir, Mehmet Eray; Aksoy, AdilThe aim of the present study was to evaluate the treatment potential of Punica granatum L. peel powder in an experimentally induced sepsis model in rats. Sepsis was induced in 10-week-old, male, Wistar Albino (n=24) rats. The animals were divided into four groups: Sham-operated (S) Group, Control (C) Group, Treatment-1 (T1) Group, and Treatment-2 (T2) Group. To induce the sepsis model, the cecal ligation and puncture procedure was performed. The P. granatum peel powder (200 mg/kg; per os) was applied one hour before (T1) and 10 hours after (T2) surgery in a volume of 2 mL. At the end of the experimental procedure, microbial and histopathological analyses were performed. The histopathological scores on the liver, lungs, heart, kidney, spleen, and pancreas were evaluated. Escherichia coli, Staphylococcus aureus and E. coli + S. aureus were isolated from blood cultures. Severe bacteria were detected in the blood of the group C animals. It was found that there were fewer bacteria in groups T1 (n=2) and T2 (n=4) compared with group C. There were no lesions in the pancreas tissues of any groups. Vascular changes, degeneration, and necrosis were common in the organs in all cases of group C compared to group S. The findings in group T1 were similar to those in group C, however, it was seen in fewer animals. It was determined that there was a general improvement in group T2, and in addition the existing lesions were moderate in severity. In conclusion, P. granatum L. peel powder prevented CLP-induced lung injury in experimental rats. Thus, P. granatum L. peel powder may be an alternative therapeutic agent against lung tissue injury induced by sepsis. The recovery from inflammation was better in group T2 than in the other groups. According to the results of the current study, P. granatum peel powder was found to be effective in the treatment of sepsis with antimicrobial and anti-inflammatory functions.Öğe Response of Probiotics and Yeast Added in Different Doses to Rations of Anatolian Merino Lambs on Fattening Performance, Meat Quality, Duodenum and Rumen Histology(Kafkas Univ, Veteriner Fakultesi Dergisi, 2021) Tekce, Emre; Bayraktar, Bulent; Aksakal, Vecihi; Dertli, Enes; Kamiloglu, Aybike; Karaalp, Musa; Timurkaan, SemaThis study investigated the effects of dietary probiotics (Lactobacillus reuteri E81 [LRE], Lactobacillus rhamnosus GG [LRG]), yeast (Saccharomyces cerevisiae S81 [SCSI), and their combined supplementation on fattening performance (BW, DWG, Fl, and FCR), meat quality, and rumen and duodenum histology in lambs. The study material comprised ninety 2.5-month-old Anatolian Merino lambs, and the trial was conducted for 70 days. Nine trial groups, each composed of 10 animals, were established. This study demonstrated that, when compared to the control group, the best fattening performance was achieved in the lambs that received 600 ppm of dietary LRE. Neither visceral organ weights nor rumen and duodenum histology was affected in the groups that received the tested feed supplements. Of the meat colour parameters investigated, the L* value was observed to have increased in the groups that were given feed supplements, excluding Groups LRE-600 and SCS-300. It was determined that the probiotic supplements had no effect on the a* and b* colour parameters, but affected the meat pH value. In conclusion, the assessment of the effects of different doses of dietary probiotics, yeast, and probiotic-yeast combinations on performance parameters, visceral organ weights, and meat quality in Anatolian Merino lambs showed that the best results were achieved in the group that received 600 ppm of LRE alone.Öğe Salivary apelin hormone response and dysfunctional attitudes in adolescents in Türkiye: a relational screening model(Springernature, 2024) Kirbas, Zila Ozlem; Bayraktar, Bulent; Aktas, Elif OdabasiBackgroundAdolescence is the period in which physical and emotional changes occur through hormones, the individual acquires gender characteristics and prepares for the adult role psychologically and physically. Dysfunctional attitudes are beliefs and attitudes that can lead to depression by causing negative thoughts about oneself, others, and the future.Dysfunctional attitudes negatively affect children's mental health. Hormones have a significant impact on human behavior and cognitive functions. However, little is known about the role and influence of hormones on dysfunctional attitudes. Apelin is a hormone responsible for controlling emotions by regulating emotional behavior. The level of dysfunctional attitudes is one of the important issues in nursing practice in terms of protecting and improving children's mental health. However, little is known about the role and impact of hormones on dysfunctional attitudes.This study aimed to examine adolescents' dysfunctional attitudes and salivary apelin hormone levels in terms of sociodemographic variables.MethodsThe study was conducted in a relational screening model with 151 adolescents aged 9-14 years who were reported to be clinically healthy in Turkiye. Apelin hormone levels were analyzed by ELISA technique in the saliva samples of the participants. In the evaluation of dysfunctional attitudes, the relationship between the score obtained from the dysfunctional attitude scale and salivary hormone levels was evaluated.ResultsIn the study, a negative, strong and statistically significant correlation was found between the average salivary apelin hormone level and dysfunctional attitudes of adolescents (p =.000). Mean salivary hormone levels of apelin in adolescent girls and boys were 0.696 (SD 0.052) ng/ml, respectively; while 0.671 (SD 0.047) ng/ml was determined (p =.002), dysfunctional attitudes scale scores were 52.95 (SD 14.43); it was determined as 59.04 (SD 14.22) (p =.006). On the other hand, the highest average salivary apelin hormone level (p =.038). and the lowest level of dysfunctional attitudes were determined in adolescent girls aged 13-14 years (p =.028).ConclusionsIn our study, we found that while the salivary apelin hormone levels of adolescents decreased, their dysfunctional attitudes increased. We found that adolescents' dysfunctional attitudes decreased with age. In contrast, apelin hormone levels increased with age. Our study revealed the relationship between the hormone apelin and dysfunctional attitudes in adolescents.The level of dysfunctional attitudes that play a role in the development of depression is lower in female adolescents than in male adolescents.Apelin level recommended to be used in the treatment of depression is higher in female adolescents than male adolescents.Apelin levels increase with age in adolescents, and dysfunctional attitude levels decrease.Öğe salivary apelin hormone response and dysfunctional attitudes in adolescents in Türkiye: a relational screening model (vol 12, 64, 2024)(Springernature, 2024) Kirbas, Zila Ozlem; Bayraktar, Bulent; Aktas, Elif Odabasi[Abstract Not Available]Öğe The relationship between emotional intelligence levels, stress management skills and hormonal and cerebral responses in university students(Springernature, 2025) Bayraktar, Bulent; Battal, FetullahBackground Emotional intelligence is a person's ability, capacity and ability to understand, use, understand, manage, anticipate, manage and direct the emotions of oneself or others. Students with high levels of emotional intelligence express themselves better, are more resistant to stress in their lives, and are individuals who can direct their emotions. Leaders with strong emotional intelligence will create synergy for all employees. Therefore, emotional intelligence and stress management skills are important issues in the field of leadership and organizational behavior. At the same time, emotional intelligence and stress management skills interact with hormones. This study aims to examine the emotional intelligence levels and hormone (apelin, cortisol) and cerebral (Brain-derived neurotrophic factor (BDNF)) response of 4th-year students of the faculty of health sciences at the university, who are potential managers of the future in terms of some variables. Methods The research was conducted using the cross-sectional data method with 167 university students aged 18-24 who were reported to be clinically healthy in T & uuml;rkiye. Apelin, cortisol hormone and BDNF levels in the participants' saliva samples were analyzed using the ELISA technique. The relationship between emotional intelligence level and total scores from the stress coping scale and salivary apelin, cortisol and BDNF levels were evaluated. Results In the study, it was determined that the average level of apelin hormone in saliva was 2.36 +/- 0.076)'' ng/mL in girls and 2.57 +/- 0.071'' ng/mL in boys. In girls, the BDNF level was 3.19 +/- 0.97'' and the cortisol level was 2.04 +/- 0.72''. BDNF level in boys is 3.41 +/- 0.94''and cortisol level is 1.92 +/- 0.59''. There is a significant difference between the participants' allowances (income levels) and the average levels of salivary apelin hormone, BDNF and emotional intelligence scale (p < 0.01). A positive, strong and statistically significant relationship was found between the participants' emotional intelligence level and stress management skills and apelin and BDNF levels, and a negative, strong and statistically significant relationship was found between salivary cortisol levels (p<0.01). Conclusions High emotional intelligence and stress management skills are an important element of strategic importance for a successful management and professional success process in individuals who will work in fields that need people such as health, marketing, law, consultancy, medicine, teaching and the service sector. Our study determined that as university students' emotional intelligence levels strengthened, the participants' stress management skills, salivary apelin, and BDNF levels increased, and cortisol hormone levels decreased. As a result, monitoring and examining apelin, BDNF, cortisol hormones can be useful parameters in evaluating the interaction between individuals' emotional intelligence level and stress management skills and hormone response.Öğe The Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study(Wiley, 2025) Okur, Suheyb; Bayraktar, Bulent; Kose, Fatma TosunPurpose The main objective of this study is to non-invasively investigate the relationship between metacognitive beliefs and cortisol, the primary stress output of the hypothalamic-pituitary-adrenal (HPA) axis, as well as neurotrophic factors associated with neuroplasticity brain-derived neurotrophic factor and neuron-derived neurotrophic factor (BDNF and NDNF). Within this framework, the hypotheses that negative metacognitions would be associated with increased cortisol and decreased BDNF levels, and that cortisol might play a mediating role in this relationship, were tested.Method The study was designed in a cross-sectional model with 60 university students. Participants' metacognitive beliefs were measured using the Metacognitions Questionnaire-30 (MCQ-30). Salivary cortisol, BDNF, and NDNF levels were analyzed using the ELISA method. Pearson correlation and hierarchical multiple regression analyses were used for data analysis.Finding The results showed a significant positive relationship between the total metacognition score and cortisol (r = 0.589, p < 0.01) and a strong negative relationship between cortisol and BDNF (r = -0.662, p < 0.01). Hierarchical regression analysis supported a partial mediation model, indicating that dysfunctional metacognitive beliefs have both a significant direct negative association with BDNF and an indirect association mediated by cortisol. In the final model, both metacognition (beta = -0.298, p < 0.05) and cortisol (beta = -0.281, p < 0.05) were significant factors associated with lower BDNF levels. NDNF showed a positive relationship with BDNF (r = 0.571) but not with other variables.Conclusion These findings point to a psychobiological model where dysfunctional metacognitive beliefs are linked to suppressed neuroprotective mechanisms like BDNF, both directly and indirectly through HPA axis activation. The results shed light on the potential neurobiological mechanisms underlying the effectiveness of metacognitive therapies.
