Effect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Agricultural Research Communication Centre
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein ( Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.
Açıklama
Anahtar Kelimeler
Apelin, cTnI, Moringa oleifera, Nesfatin-1, Rat, Type 1 Diabetes mellitus, Visfatin
Kaynak
Indian Journal of Animal Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
59
Sayı
1
