Effect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats

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dc.contributor.authorOrkun Erkilic, Tugce
dc.contributor.authorBayraktar, Bulent
dc.date.accessioned2026-02-28T12:18:10Z
dc.date.available2026-02-28T12:18:10Z
dc.date.issued2025
dc.departmentBayburt Üniversitesi
dc.description.abstractBackground: The aim of this study was to investigate the effects of Moringa oleifera extract (MOE) added to the diets at different amounts on Adipokine (apelin, visfatin and nesfatin-1) and Cardiac (cardiac troponin I (cTnI)) Response in Streptozotocin (STZ)-induced Type 1 diabetic rats. Methods: In this study, 64 adult male Wistar albino rats, aged between 8-10 weeks, were used. Eight (8) groups were created, with 8 rats in each group: Control (C), M100 (MOE 100 mg/kg group given with oral gavage route of administration (OGRA), M200 (MOE 200 mg/kg group given with OGRA), M300 (MOE 300 mg/kg group given with OGRA); STZ 55 mg/kg i.p administered group, Diabetic control group (DC), DM100 (D+100 mg/kg MOE), DM200 (D+200 mg/kg MOE), DM300 (D)+300 mg/kg MOE). The study lasted a total of 31 days, including adaptation (7 days), induction of diabetes (3 days) and trial period (21 days). Blood samples were taken from the tail vein ( Vena caudalis) of all subMects on days 0 and 21 of the study. Apelin, visfatin, nesfatin-1 and cTnI levels in the serum samples were measured by ELISA method. Result: In the present study, the most significant increase in mean serum apelin, visfatin, nesfatin-1 and cTnI levels in diabetes groups was observed in DC groups, while the most significant decrease due to MOE addition was observed in DM200 groups (p<0.01). As a result, it was concluded that MOE may be safe and beneficial when administered at a dose of 200 mg/kg in rats with STZ-induced diabetes.
dc.identifier.doi10.18805/IJAR.BF-1904
dc.identifier.endpage113
dc.identifier.issn0367-6722
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85216837789
dc.identifier.scopusqualityQ3
dc.identifier.startpage108
dc.identifier.urihttps://doi.org/10.18805/IJAR.BF-1904
dc.identifier.urihttps://hdl.handle.net/20.500.12403/6142
dc.identifier.volume59
dc.identifier.wosWOS:001412804800015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260218
dc.subjectApelin
dc.subjectcTnI
dc.subjectMoringa oleifera
dc.subjectNesfatin-1
dc.subjectRat
dc.subjectType 1 Diabetes mellitus
dc.subjectVisfatin
dc.titleEffect of Moringa oleifera Oil Extract on Adipokine (Apelin, Visfatin and Nesfatin-1) and Cardiac (cTnI) Response in Streptozotocin-induced Rats
dc.typeArticle

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